PMID- 23756767
OWN - NLM
STAT- MEDLINE
DCOM- 20140408
LR  - 20211203
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Linking)
VI  - 91
IP  - 10
DP  - 2013 Oct
TI  - mTOR and regulation of energy homeostasis in humans.
PG  - 1167-75
LID - 10.1007/s00109-013-1057-6 [doi]
AB  - Patients treated with the mammalian or mechanistic target of rapamycin (mTOR) 
      inhibitor everolimus in order to slow progression of autosomal-dominant 
      polycystic kidney disease (ADPKD) showed a significant reduction of body weight. 
      Although the detailed mechanism of how mTOR inhibition interferes with body 
      weight regulation is rather unclear, present data suggest that this effect is 
      mediated by both central and peripheral mechanisms. These findings in ADPKD 
      patients are in contrast to well-documented effects of hypothalamic mTOR on 
      regulation of energy homeostasis and eating behavior in rodents. In a number of 
      rodent models, the mTOR inhibitor rapamycin induces increased food intake, which 
      is accompanied by increased body weight. However, animal data are inconsistent. 
      This review highlights some of the regulatory signals and key mechanisms that are 
      important for balancing energy intake and energy expenditure with a special focus 
      on adipose tissue-derived adipokines and their interaction with mTOR regarding 
      local regulation of tissue perfusion and metabolism and overall systemic energy 
      homeostasis. Specifically, clinical aspects of an impaired mTOR signaling pathway 
      regarding the development of obesity and type-2 diabetes mellitus will be 
      discussed.
FAU - Mannaa, Marwan
AU  - Mannaa M
AD  - Campus Virchow Klinikum, Medical Department, Division of Nephrology and Medical 
      Intensive Care Medicine, Charite-Universitatsmedizin Berlin, Augustenburger Platz 
      1, 13353, Berlin, Germany, marwan.mannaa@charite.de.
FAU - Kramer, Stephanie
AU  - Kramer S
FAU - Boschmann, Michael
AU  - Boschmann M
FAU - Gollasch, Maik
AU  - Gollasch M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130612
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (Carrier Proteins)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/metabolism
MH  - Energy Metabolism/*physiology
MH  - *Homeostasis
MH  - Humans
MH  - Protein Binding
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
EDAT- 2013/06/13 06:00
MHDA- 2014/04/09 06:00
CRDT- 2013/06/13 06:00
PHST- 2012/12/10 00:00 [received]
PHST- 2013/05/16 00:00 [accepted]
PHST- 2013/05/09 00:00 [revised]
PHST- 2013/06/13 06:00 [entrez]
PHST- 2013/06/13 06:00 [pubmed]
PHST- 2014/04/09 06:00 [medline]
AID - 10.1007/s00109-013-1057-6 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2013 Oct;91(10):1167-75. doi: 10.1007/s00109-013-1057-6. Epub 
      2013 Jun 12.