PMID- 23757959
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20161125
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 19
IP  - 5
DP  - 2013 May
TI  - [Effects of plasma Hcy on the contents of CO and HO-2 in the corpus cavernosum of 
      ED rats with hyperhomocysteinemia].
PG  - 398-402
AB  - OBJECTIVE: To study the changes in the activities of carbon monoxide (CO) and 
      heme oxygenase 2 (HO-2) in ED rats with hyperhomocysteinemia (HHcy). METHODS: 
      This study included 40 male Wistar rats weighing 280 - 310 g, 10 as normal 
      controls (group A). HHcy models were made in the other 30 by giving 3% methionine 
      for 4 weeks, and then divided into groups B, C and D. The rats in group B 
      continued to be fed with 3% methionine, those in group C were treated with 
      betaine hydrochloride, and those in group D were given zinc porphyrin IX at 45 
      micromol per kg per d. Penile erections of the rats were recorded, and 4 weeks 
      later, all were killed for determination of the levels of homocysteine (Hcy) in 
      the blood plasma and the activities of CO and HO-2 in the corpus cavernosum of 
      the penis. RESULTS: The level of plasma Hcy, penile erection frequency and the 
      content of CO in the corpus cavernosum were (12.55 +/- 0.82) micromol/L, (1.88 
      +/- 0.05) times and (10.55 +/- 1.73) micromol/L in group A, the Hcy level 
      significantly higher while the penile erection frequency and CO content 
      remarkably lower than in group B ([25.01 +/- 0.94] micromol/L, [0.70 +/- 0.05] 
      times and [9.51 +/- 1.52] micromol/L, P < 0.05 or P < 0.01), with a negative 
      correlation between the level of Hcy and that of CO and HO-2 (P < 0.01). Compared 
      with group B, the three parameters were all significantly increased in C ([14.37 
      +/- 0.47] micromol/L, [1.18 +/- 0.08] times and [10.36 +/- 1.56] micromol/L, all 
      P < 0.05 or P < 0.01). CONCLUSION: Decreased expressions of CO and HO-2 in the 
      corpus cavernosum of the penis may result in ED in HHcy rats. Betaine can reduce 
      the Hcy level in the blood plasma and CO content in the corpus cavernosum, which 
      might be one of the mechanisms of its action on ED with HHcy.
FAU - Qin, Wen-Bo
AU  - Qin WB
AD  - Department of Urology, The Second Affiliated Hospital, Jiamusi, Heilongjiang 
      154007, China. qinwenb@sina.com
FAU - Huang, Wen-Jun
AU  - Huang WJ
FAU - Chi, Bao-Jin
AU  - Chi BJ
FAU - He, Hao-Lin
AU  - He HL
FAU - Chen, Da-Yin
AU  - Chen DY
FAU - Wang, Shu-Qiu
AU  - Wang SQ
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 7U1EE4V452 (Carbon Monoxide)
RN  - EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
RN  - EC 1.14.14.18 (heme oxygenase-2)
SB  - IM
MH  - Animals
MH  - Carbon Monoxide/blood
MH  - Erectile Dysfunction/*blood/metabolism
MH  - Heme Oxygenase (Decyclizing)/*blood
MH  - Homocysteine/*blood
MH  - Hyperhomocysteinemia/blood/*metabolism
MH  - Male
MH  - Penis/*metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2013/06/14 06:00
MHDA- 2013/11/01 06:00
CRDT- 2013/06/14 06:00
PHST- 2013/06/14 06:00 [entrez]
PHST- 2013/06/14 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2013 May;19(5):398-402.