PMID- 23759396
OWN - NLM
STAT- MEDLINE
DCOM- 20140116
LR  - 20211021
IS  - 1932-2968 (Electronic)
IS  - 1932-2968 (Linking)
VI  - 7
IP  - 3
DP  - 2013 May 1
TI  - Methodology for quantifying fasting glucose homeostasis in type 2 diabetes: 
      observed variability and lability.
PG  - 640-5
AB  - BACKGROUND: Increased glycemic variability is associated with an increase risk of 
      adverse clinical outcomes in diabetes. Central to the understanding of diabetes 
      is glucose homeostasis. "Good" homeostasis is equated to low glycemic 
      variability, and "poor" homeostasis is linked to greater glycemic variability. We 
      have, therefore, developed a method with the aim to objectively quantify the 
      domain of glucose-insulin homeostasis. We have termed this method as Observed 
      Variability And Lability (OVAL). METHOD: Blood samples for the measurement of 
      glucose and insulin concentrations were acquired every 2 min for 120 min from 12 
      patients with type 2 diabetes mellitus [T2DM; median (range) age 35 (25-47) years 
      and duration of diabetes 7 (2-9) years receiving oral hypoglycemic treatment] and 
      27 controls [aged 38(30-53) years] with an equal split of genders and equal 
      distribution of body mass indexes. The insulin-glucose time variant data form the 
      boundaries of OVAL, defined as the ellipse enclosing the 95% confidence intervals 
      of the insulin and glucose concentrations plotted on an x-y scatter graph and 
      normalized to ensure equal weighting of insulin and glucose. RESULTS: Less 
      precise OVAL homeostasis was observed in subjects with T2DM, by a factor of 4, in 
      comparison with controls [OVAL, T2DM 7.8(3.8) versus controls 1.9(1.0); p = 
      .0003]. The assessment remained statistically robust (p < .001) with increased 
      sampling intervals up to 8 min. CONCLUSION: The OVAL model is a robust method for 
      measuring glucose-insulin homeostasis in controls and T2DM subjects (available 
      online at http://www.oval-calc.co.uk). Deranged glucose-insulin homeostasis is 
      the hallmark of diabetes and OVAL has the capacity to quantify in the fasting 
      state.
CI  - (c) 2013 Diabetes Technology Society.
FAU - Hill, Nathan R
AU  - Hill NR
AD  - Department of Primary Care Health Sciences, University of Oxford, Radcliffe 
      Observatory Quarter, Woodstock Road, Oxford , United Kingdom. 
      Nathan.Hill@phc.ox.ac.uk
FAU - Tsapas, Apostolos
AU  - Tsapas A
FAU - Hindmarsh, Peter
AU  - Hindmarsh P
FAU - Matthews, David R
AU  - Matthews DR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130501
PL  - United States
TA  - J Diabetes Sci Technol
JT  - Journal of diabetes science and technology
JID - 101306166
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*analysis
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Fasting
MH  - Female
MH  - Homeostasis
MH  - Humans
MH  - Insulin/*blood
MH  - Male
MH  - Middle Aged
MH  - *Models, Statistical
PMC - PMC3869131
EDAT- 2013/06/14 06:00
MHDA- 2014/01/17 06:00
PMCR- 2014/05/01
CRDT- 2013/06/14 06:00
PHST- 2013/06/14 06:00 [entrez]
PHST- 2013/06/14 06:00 [pubmed]
PHST- 2014/01/17 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - dst.7.3.0640 [pii]
AID - 10.1177/193229681300700308 [doi]
PST - epublish
SO  - J Diabetes Sci Technol. 2013 May 1;7(3):640-5. doi: 10.1177/193229681300700308.