PMID- 23759469
OWN - NLM
STAT- MEDLINE
DCOM- 20140214
LR  - 20211021
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 47
IP  - 9
DP  - 2013 Sep
TI  - Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of 
      adult depressed suicide victims compared with controls without cardiovascular 
      disease.
PG  - 1187-91
LID - S0022-3956(13)00147-7 [pii]
LID - 10.1016/j.jpsychires.2013.05.007 [doi]
AB  - BACKGROUND: A growing body of evidence suggests that deficits in long-chain 
      omega-3 (LCn-3) fatty acids may contribute to major depressive disorder (MDD) and 
      principal causes of excess mortality including suicide and cardiovascular 
      disease. In the present study we compared concentrations of docosahexaenoic acid 
      (DHA, 22:6n-3), the principal LCn-3 fatty acid in brain, in the postmortem 
      prefrontal cortex (BA10) of adult depressed suicide victims and controls with 
      and/or without cardiovascular disease. METHODS: DHA concentrations (mumol/g) in 
      the prefrontal cortex (PFC, BA10) of adult male and female suicide victims 
      (n = 20) and controls with (n = 8) or without (n = 12) cardiovascular disease 
      were determined by gas chromatography. RESULTS: There was a non-significant trend 
      for lower DHA concentrations in suicide victims compared with all controls (-10%, 
      p = 0.06, d = 0.5). Significantly lower DHA concentrations were observed in 
      suicide victims compared with controls without cardiovascular disease (-14%, 
      p = 0.03, d = 0.7) but not controls with cardiovascular disease (-4%, p = 0.71, 
      d = 0.1). There was a non-significant trend for lower DHA concentrations in 
      controls with cardiovascular disease compared with controls without 
      cardiovascular disease (-11%, p = 0.1, d = 0.6). CONCLUSIONS: Adult depressed 
      suicide victims exhibit lower postmortem PFC DHA concentrations compared with 
      controls without cardiovascular disease. These data add to a growing body of 
      evidence implicating DHA deficits in the pathophysiology of MDD, suicide, and 
      cardiovascular disease.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - McNamara, Robert K
AU  - McNamara RK
AD  - Department of Psychiatry, University of Cincinnati College of Medicine, Medical 
      Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267-0559, USA. 
      robert.mcnamara@uc.edu
FAU - Jandacek, Ronald
AU  - Jandacek R
FAU - Tso, Patrick
AU  - Tso P
FAU - Dwivedi, Yogesh
AU  - Dwivedi Y
FAU - Ren, Xinguo
AU  - Ren X
FAU - Pandey, Ghanshyam N
AU  - Pandey GN
LA  - eng
GR  - U2C DK059630/DK/NIDDK NIH HHS/United States
GR  - R01 MH048153/MH/NIMH NIH HHS/United States
GR  - R01 MH098554/MH/NIMH NIH HHS/United States
GR  - UL1 TR000077/TR/NCATS NIH HHS/United States
GR  - U24 DK059630/DK/NIDDK NIH HHS/United States
GR  - R01 MH056528/MH/NIMH NIH HHS/United States
GR  - R34 MH083924/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130604
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 25167-62-8 (Docosahexaenoic Acids)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Chromatography, Gas
MH  - *Depression/metabolism/pathology/psychology
MH  - Docosahexaenoic Acids/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postmortem Changes
MH  - Prefrontal Cortex/*metabolism
MH  - Suicide/*psychology
PMC - PMC3710518
MID - NIHMS483621
OTO - NOTNLM
OT  - Adolescent
OT  - Docosahexaenoic acid (DHA)
OT  - Omega-3 fatty acid
OT  - Postmortem brain
OT  - Prefrontal cortex
OT  - Suicide
EDAT- 2013/06/14 06:00
MHDA- 2014/02/15 06:00
PMCR- 2014/09/01
CRDT- 2013/06/14 06:00
PHST- 2013/04/02 00:00 [received]
PHST- 2013/05/03 00:00 [revised]
PHST- 2013/05/09 00:00 [accepted]
PHST- 2013/06/14 06:00 [entrez]
PHST- 2013/06/14 06:00 [pubmed]
PHST- 2014/02/15 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - S0022-3956(13)00147-7 [pii]
AID - 10.1016/j.jpsychires.2013.05.007 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2013 Sep;47(9):1187-91. doi: 10.1016/j.jpsychires.2013.05.007. 
      Epub 2013 Jun 4.