PMID- 23760081
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20221207
IS  - 1460-2083 (Electronic)
IS  - 0964-6906 (Linking)
VI  - 22
IP  - 20
DP  - 2013 Oct 15
TI  - A genome-wide association study identified new variants associated with the risk 
      of chronic hepatitis B.
PG  - 4233-8
LID - 10.1093/hmg/ddt266 [doi]
AB  - Hepatitis B virus (HBV) infection is the predominant risk factor for chronic 
      hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). 
      Recently, several genome-wide association studies (GWASs) of CHB identified human 
      leukocyte antigen (HLA) loci, including HLA-DP and HLA-DQ in Asian populations, 
      as being associated with the risk of CHB. To confirm and identify the host 
      genetic factors related to CHB infection, we performed another GWAS using a 
      higher-density chip in Korean CHB carriers. We analyzed 1400 samples from Korean 
      population (400 CHB cases and 1000 population controls) using a higher-density 
      GWAS chip [1 140 419 single nucleotide polymorphisms (SNPs)]. In subsequent 
      replication analysis, we further analyzed in an independent study of a Korean CHB 
      cohort consisting of 2909 Korean samples (971 cases and 1938 controls). Logistic 
      regression methods were used for statistical analysis adjusting for age and sex 
      as covariates. This study identified two new risk-associated loci for CHB on the 
      HLA region of chromosome 6, e.g. rs652888 on euchromatic 
      histone-lysine-methyltransferase 2 (EHMT2, P = 7.07 x 10(-13)) and rs1419881 on 
      transcription factor 19 (TCF19, P = 1.26 x 10(-18)). Conditional analysis with 
      nearby HLA CHB loci that were previously known, confirmed the independent genetic 
      effects of these two loci on CHB. CONCLUSION: The GWAS and the subsequent 
      validation study identified new variants associated with the risk of CHB. These 
      findings may advance the understanding of genetic susceptibility to CHB.
FAU - Kim, Yoon Jun
AU  - Kim YJ
FAU - Kim, Hwi Young
AU  - Kim HY
FAU - Lee, Jeong-Hoon
AU  - Lee JH
FAU - Yu, Su Jong
AU  - Yu SJ
FAU - Yoon, Jung-Hwan
AU  - Yoon JH
FAU - Lee, Hyo-Suk
AU  - Lee HS
FAU - Kim, Chung Yong
AU  - Kim CY
FAU - Cheong, Jae Youn
AU  - Cheong JY
FAU - Cho, Sung Won
AU  - Cho SW
FAU - Park, Neung Hwa
AU  - Park NH
FAU - Park, Byung Lae
AU  - Park BL
FAU - Namgoong, Seok
AU  - Namgoong S
FAU - Kim, Lyoung Hyo
AU  - Kim LH
FAU - Cheong, Hyun Sub
AU  - Cheong HS
FAU - Shin, Hyoung Doo
AU  - Shin HD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130610
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (TCF19 protein, human)
RN  - 0 (Transcription Factors)
RN  - EC 2.1.1.43 (EHMT2 protein, human)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Age Factors
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 6
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - *Genome-Wide Association Study
MH  - Hepatitis B, Chronic/*genetics
MH  - Histocompatibility Antigens/*genetics
MH  - Histone-Lysine N-Methyltransferase/*genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sex Distribution
MH  - Transcription Factors/*genetics
EDAT- 2013/06/14 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/06/14 06:00
PHST- 2013/06/14 06:00 [entrez]
PHST- 2013/06/14 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - ddt266 [pii]
AID - 10.1093/hmg/ddt266 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2013 Oct 15;22(20):4233-8. doi: 10.1093/hmg/ddt266. Epub 2013 Jun 
      10.