PMID- 23761264
OWN - NLM
STAT- MEDLINE
DCOM- 20140408
LR  - 20240323
IS  - 1530-9932 (Electronic)
IS  - 1530-9932 (Linking)
VI  - 14
IP  - 3
DP  - 2013 Sep
TI  - Polydimethylsiloxane-indomethacin blends and nanoparticles.
PG  - 968-76
LID - 10.1208/s12249-013-9989-2 [doi]
AB  - A series of blends of polydimethylsiloxane (PDMS) and indomethacin (IMC), 
      containing 20-80 wt.% IMC were obtained and characterized by differential 
      scanning calorimetry, Fourier transform-infrared spectroscopy, and powder X-ray 
      diffraction in order to observe the mutual influence of the two components. The 
      main thermal transitions of PDMS remained un-changed. Both the solvent 
      (tetrahydrofuran, THF) and the PDMS influenced the crystalline form of IMC. The 
      blends were subsequently re-dissolved in THF, with or without cross-linking 
      reagents added and precipitated into diluted aqueous solutions of siloxane-based 
      surfactants. The resulted nanoparticles were analyzed by dynamic light scattering 
      and scanning electron microscopy. Most of the particles had diameters between 200 
      and 300 nm. The surfactants, the IMC content and the cross-linking influenced the 
      particles size and polydispersity, as well as the nanoparticle yield. The maximum 
      drug release from selected aqueous formulations was 30%.
FAU - Racles, Carmen
AU  - Racles C
AD  - Petru Poni Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41A, 
      700487, Iasi, Romania. raclesc@icmpp.ro
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130613
PL  - United States
TA  - AAPS PharmSciTech
JT  - AAPS PharmSciTech
JID - 100960111
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 63148-62-9 (baysilon)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*chemistry
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Indomethacin/*chemistry
MH  - Microscopy, Electron, Scanning
MH  - *Nanoparticles
MH  - Powder Diffraction
MH  - Spectroscopy, Fourier Transform Infrared
PMC - PMC3755148
EDAT- 2013/06/14 06:00
MHDA- 2014/04/09 06:00
PMCR- 2014/06/13
CRDT- 2013/06/14 06:00
PHST- 2013/02/12 00:00 [received]
PHST- 2013/05/28 00:00 [accepted]
PHST- 2013/06/14 06:00 [entrez]
PHST- 2013/06/14 06:00 [pubmed]
PHST- 2014/04/09 06:00 [medline]
PHST- 2014/06/13 00:00 [pmc-release]
AID - 9989 [pii]
AID - 10.1208/s12249-013-9989-2 [doi]
PST - ppublish
SO  - AAPS PharmSciTech. 2013 Sep;14(3):968-76. doi: 10.1208/s12249-013-9989-2. Epub 
      2013 Jun 13.