PMID- 23762154 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130614 LR - 20211021 IS - 1741-427X (Print) IS - 1741-4288 (Electronic) IS - 1741-427X (Linking) VI - 2013 DP - 2013 TI - Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models. PG - 709865 LID - 10.1155/2013/709865 [doi] LID - 709865 AB - Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as a medicine since ancient times by many cultures. The ethanolic extract of Resina Draconis (RDEE) was evaluated for its wound-healing activity using excision and incision wound models in rats. Group I, the control group, was treated with ointment base. Group II, which served as a reference standard, was treated with moist exposed burn ointment (MEBO). Group III was treated with RDEE. The parameters observed were percentage of wound contraction, epithelialization period, tensile strength, histopathological studies, microvessel density (MVD), and the expression of vascular endothelial growth factor (VEGF) and transforming growth factor- beta 1 (TGF- beta 1). The group treated with RDEE showed significantly better wound contraction and better skin-breaking strength as compared with the control group. The results of histopathological examination, MVD, and the expression levels of growth factors supported the outcome of the wound models as well. The present study provided a scientific rationale for the traditional use of RD in the management of wounds. FAU - Liu, Huihui AU - Liu H AD - Department of General Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. FAU - Lin, Shaohui AU - Lin S FAU - Xiao, Dan AU - Xiao D FAU - Zheng, Xiao AU - Zheng X FAU - Gu, Yan AU - Gu Y FAU - Guo, Shanyu AU - Guo S LA - eng PT - Journal Article DEP - 20130516 PL - United States TA - Evid Based Complement Alternat Med JT - Evidence-based complementary and alternative medicine : eCAM JID - 101215021 PMC - PMC3670512 EDAT- 2013/06/14 06:00 MHDA- 2013/06/14 06:01 PMCR- 2013/05/16 CRDT- 2013/06/14 06:00 PHST- 2013/02/05 00:00 [received] PHST- 2013/04/07 00:00 [revised] PHST- 2013/04/08 00:00 [accepted] PHST- 2013/06/14 06:00 [entrez] PHST- 2013/06/14 06:00 [pubmed] PHST- 2013/06/14 06:01 [medline] PHST- 2013/05/16 00:00 [pmc-release] AID - 10.1155/2013/709865 [doi] PST - ppublish SO - Evid Based Complement Alternat Med. 2013;2013:709865. doi: 10.1155/2013/709865. Epub 2013 May 16.