PMID- 23763520
OWN - NLM
STAT- MEDLINE
DCOM- 20140429
LR  - 20140312
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 54
IP  - 3
DP  - 2014 Mar
TI  - The minimum number of cord blood units needed for Koreans is 51,000.
PG  - 504-8
LID - 10.1111/trf.12284 [doi]
AB  - BACKGROUND: The inventory size for cord blood (CB) depends on the ethnic 
      diversity of human leukocyte antigen (HLA) and the size estimation is important 
      for public health in each ethnicity. STUDY DESIGN AND METHODS: We estimate the CB 
      inventory size in Koreans with stored CB units (CBUs) and patients who underwent 
      allogeneic hematopoietic stem cell transplantation. Two-digit HLA specificities 
      were determined using intermediate DNA typing. From 17,508 stored Korean CBUs, 
      1460 haplotypes with a frequency greater than 0.001% were used for reconstitution 
      of the HLA. A total of 1002 transplanted patients' HLA was used for matching 
      probability calculation. RESULTS: The best probability for 6/6 matching is 47% in 
      500,000 hypothetical size. Ninety-five percent probability is achieved with 
      51,000 CBUs in 5/6, and 2150 in 4/6 matching condition. Because 4/6 matched CB is 
      rarely selected in the Korean situation, 51,000 units is the lowest limit of CBUs 
      required and the number will be adjusted depending on the cell number required 
      for patients and the resolution of HLA typing. CONCLUSION: Approximately 51,000 
      units could provide the minimum requirement for hematopoietic transplantation in 
      Korea.
CI  - (c) 2013 American Association of Blood Banks.
FAU - Yoon, Jong Hyun
AU  - Yoon JH
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea; Department of Laboratory Medicine, Biostatistics, Boramae Hospital, 
      Seoul, Korea; Seoul Metropolitan Government Public Cord Blood Bank (Allcord), 
      Seoul, Korea.
FAU - Oh, Sohee
AU  - Oh S
FAU - Shin, Sue
AU  - Shin S
FAU - Park, Jeong Soo
AU  - Park JS
FAU - Roh, Eun Youn
AU  - Roh EY
FAU - Song, Eun Young
AU  - Song EY
FAU - Park, Myoung Hee
AU  - Park MH
FAU - Han, Kyou Sup
AU  - Han KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130613
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
SB  - IM
CIN - Transfusion. 2014 Mar;54(3):499-500. PMID: 24617584
MH  - Blood Banks/*statistics & numerical data
MH  - Cord Blood Stem Cell Transplantation
MH  - Female
MH  - *Fetal Blood
MH  - Humans
MH  - Pregnancy
MH  - Republic of Korea
EDAT- 2013/06/15 06:00
MHDA- 2014/04/30 06:00
CRDT- 2013/06/15 06:00
PHST- 2013/02/19 00:00 [received]
PHST- 2013/04/18 00:00 [revised]
PHST- 2013/04/23 00:00 [accepted]
PHST- 2013/06/15 06:00 [entrez]
PHST- 2013/06/15 06:00 [pubmed]
PHST- 2014/04/30 06:00 [medline]
AID - 10.1111/trf.12284 [doi]
PST - ppublish
SO  - Transfusion. 2014 Mar;54(3):504-8. doi: 10.1111/trf.12284. Epub 2013 Jun 13.