PMID- 23763615
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20140818
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 19
IP  - 5
DP  - 2014 Sep
TI  - Acquisition of MDMA self-administration: pharmacokinetic factors and MDMA-induced 
      serotonin release.
PG  - 874-84
LID - 10.1111/adb.12069 [doi]
AB  - The current study aimed to elucidate the role of pharmacokinetic (PK) parameters 
      and neurotransmitter efflux in explaining variability in (+/-) 3, 
      4-methylenedioxymethamphetamine (MDMA) self-administration in rats. PK profiles 
      of MDMA and its major metabolites were determined after the administration of 
      1.0 mg/kg MDMA (iv) prior to, and following, the acquisition of MDMA 
      self-administration. Synaptic levels of 5-hydroxytryptamine (5HT) and dopamine 
      (DA) in the nucleus accumbens were measured following administration of MDMA (1.0 
      and 3.0 mg/kg, iv) using in vivo microdialysis and compared for rats that 
      acquired or failed to acquire MDMA self-administration. Effects of the 5HT 
      neurotoxin, 5,7 dihydroxytryptamine (5, 7-DHT), on the acquisition of MDMA and 
      cocaine self-administration were also determined. In keeping with previous 
      findings, approximately 50% of rats failed to meet a criterion for acquisition of 
      MDMA self-administration. The PK profiles of MDMA and its metabolites did not 
      differ between rats that acquired or failed to acquire MDMA self-administration. 
      MDMA produced more overflow of 5HT than DA. The MDMA-induced 5HT overflow was 
      lower in rats that acquired MDMA self-administration compared with those that did 
      not acquire self-administration. In contrast, MDMA-induced DA overflow was 
      comparable for the two groups. Prior 5,7-DHT lesions reduced tissue levels of 5HT 
      and markedly increased the percentage of rats that acquired MDMA 
      self-administration and also decreased the latency to acquisition of cocaine 
      self-administration. These data suggest that 5HT limits the initial sensitivity 
      to the positively reinforcing effects of MDMA and delays the acquisition of 
      reliable self-administration.
CI  - (c) 2013 Society for the Study of Addiction.
FAU - Bradbury, Sarah
AU  - Bradbury S
AD  - School of Psychology, Victoria University of Wellington, New Zealand.
FAU - Bird, Judith
AU  - Bird J
FAU - Colussi-Mas, Joyce
AU  - Colussi-Mas J
FAU - Mueller, Melanie
AU  - Mueller M
FAU - Ricaurte, George
AU  - Ricaurte G
FAU - Schenk, Susan
AU  - Schenk S
LA  - eng
PT  - Journal Article
DEP - 20130614
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Serotonin Agents)
RN  - 31363-74-3 (5,7-Dihydroxytryptamine)
RN  - 333DO1RDJY (Serotonin)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 5,7-Dihydroxytryptamine/pharmacology
MH  - Animals
MH  - Area Under Curve
MH  - Cocaine/administration & dosage/pharmacology
MH  - Conditioning, Operant/drug effects
MH  - Dopamine/metabolism
MH  - Dopamine Uptake Inhibitors/pharmacology
MH  - Infusions, Intravenous
MH  - Male
MH  - Microdialysis/methods
MH  - N-Methyl-3,4-methylenedioxyamphetamine/metabolism/*pharmacokinetics
MH  - Nucleus Accumbens/metabolism
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/*pharmacology
OTO - NOTNLM
OT  - Dopamine
OT  - MDMA
OT  - microdialysis
OT  - pharmacokinetics
OT  - self-administration
OT  - serotonin
EDAT- 2013/06/15 06:00
MHDA- 2015/05/12 06:00
CRDT- 2013/06/15 06:00
PHST- 2013/06/15 06:00 [entrez]
PHST- 2013/06/15 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - 10.1111/adb.12069 [doi]
PST - ppublish
SO  - Addict Biol. 2014 Sep;19(5):874-84. doi: 10.1111/adb.12069. Epub 2013 Jun 14.