PMID- 23764988
OWN - NLM
STAT- MEDLINE
DCOM- 20140206
LR  - 20220318
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 27
IP  - 9
DP  - 2013 Sep
TI  - Ocular perfusion pressure and choroidal thickness in eyes with polypoidal 
      choroidal vasculopathy, wet-age-related macular degeneration, and normals.
PG  - 1038-43
LID - 10.1038/eye.2013.106 [doi]
AB  - PURPOSE: To measure the choroidal thickness and ocular perfusion pressure in eyes 
      with polypoidal choroidal vasculopathy (PCV), wet-age-related macular 
      degeneration (AMD), and age-matched normal subjects, and look for a possible 
      association between the two. METHODS: This was a prospective study including 22 
      eyes with PCV, 33 eyes with wet-AMD, and 35 age-matched normal eyes. Choroidal 
      thickness was measured using enhanced depth imaging (EDI) with spectral-domain 
      optical coherence tomography (SD OCT). Mean ocular perfusion pressure (MOPP) was 
      calculated using the mathematical formula 2/3[DBP+1/3SBP x DBP]-IOP 
      (DBP-diastolic blood pressure, SBP-systolic blood pressure, IOP-intraocular 
      pressure). Analyses were carried out using SPSS 14 software and comparisons of 
      mean made using't' tests. RESULTS: Eyes with PCV showed increased (285.9 mum; 
      subfoveal) choroidal thickness, whereas eyes with wet-AMD (119.4 mum; subfoveal) 
      showed reduced choroidal thickness in comparison with normal eyes (186.77 mum; 
      subfoveal). MOPP in the PCV group was 57.85 mm Hg (P value 0.00), in the wet-AMD 
      group was 52.1 mm Hg (P-value 0.12), and in the normal group was 49.79 mm Hg. 
      CONCLUSION: It is postulated that higher MOPP in eyes with PCV could have an 
      etiologic implication in disease manifestation and progression. Larger studies 
      with longer follow-up may help validate these findings.
FAU - Rishi, P
AU  - Rishi P
AD  - Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralya, Chennai, India.
FAU - Rishi, E
AU  - Rishi E
FAU - Mathur, G
AU  - Mathur G
FAU - Raval, V
AU  - Raval V
LA  - eng
PT  - Journal Article
DEP - 20130614
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Aged
MH  - Blood Pressure/physiology
MH  - Case-Control Studies
MH  - Choroid/blood supply/*pathology
MH  - Choroid Diseases/pathology/*physiopathology
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Macular Degeneration/pathology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Tomography, Optical Coherence
PMC - PMC3772351
EDAT- 2013/06/15 06:00
MHDA- 2014/02/07 06:00
PMCR- 2014/09/01
CRDT- 2013/06/15 06:00
PHST- 2013/01/09 00:00 [received]
PHST- 2013/04/23 00:00 [accepted]
PHST- 2013/06/15 06:00 [entrez]
PHST- 2013/06/15 06:00 [pubmed]
PHST- 2014/02/07 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - eye2013106 [pii]
AID - 10.1038/eye.2013.106 [doi]
PST - ppublish
SO  - Eye (Lond). 2013 Sep;27(9):1038-43. doi: 10.1038/eye.2013.106. Epub 2013 Jun 14.