PMID- 23766268
OWN - NLM
STAT- MEDLINE
DCOM- 20150403
LR  - 20181202
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 29
IP  - 12
DP  - 2014 Dec
TI  - Semiquinone fraction isolated from Bacillus sp. INM-1 protects hepatic tissues 
      against gamma-radiation induced toxicity.
PG  - 1471-8
LID - 10.1002/tox.21877 [doi]
AB  - Present study was focused on evaluation of a semiquinone glucoside derivative 
      (SQGD) isolated from radioresistant bacterium Bacillus sp. INM-1 for its ability 
      against gamma radiation induced oxidative stress in irradiated mice. Animals were 
      divided into four group, i.e., (i) untreated control mice; (ii) SQGD treated (50 
      mg/kg b. wt. i.p.) mice; (iii) irradiated (10 Gy) mice; and (iv) irradiated mice 
      which were pre-treated (-2 h) with SQGD (50 mg/kg b. wt. i.p.). Following 
      treatment, liver homogenates of the treated mice were subjected to endogenous 
      antioxidant enzymes estimation. Result indicated that SQGD pre-treatment, 
      significantly (P < 0.05) induced superoxide dismutase (SOD) (19.84 +/- 2.18% at 72 
      h), catalase (CAT) (26.47 +/- 3.11% at 12 h), glutathione (33.81 +/- 1.99% at 24 h), 
      and glutathione-S-transferase (24.40 +/- 2.65% at 6 h) activities in the liver of 
      mice as compared with untreated control. Significant (P < 0.05) induction in SOD 
      (50.04 +/- 5.59% at 12 h), CAT (62.22 +/- 7.50 at 72 h), glutathione (42.92 +/- 2.28% 
      at 24 h), and glutathione-S-transferase (46.65 +/- 3.25 at 12 h) was observed in 
      irradiated mice which were pre-treated with SQGD compared with only irradiated 
      mice. Further, significant induction in ABTS(+) radicals (directly proportional 
      to decrease mM Trolox equivalent) was observed in liver homogenate of H2 O2 
      treated mice which were found to be significantly inhibited in H2 O2 treated mice 
      pre-treated with SQGD. Thus, it can be concluded that SQGD treatment neutralizes 
      oxidative stress caused by irradiation not only by enhancing endogenous 
      antioxidant enzymes but also by improving total antioxidant status of cellular 
      system and thus cumulative effect of the phenomenon may contributes to 
      radioprotection.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Mishra, Saurabh
AU  - Mishra S
AD  - Radiation Biotechnology Laboratory, Department of Radiation Biosciences, 
      Institute of Nuclear Medicine and Allied Sciences, Delhi, 110054, India.
FAU - Bansal, Deen Dayal
AU  - Bansal DD
FAU - Malhotra, Poonam
AU  - Malhotra P
FAU - K Reddy, D Sudheer
AU  - K Reddy DS
FAU - Jamwal, Vishawdeep S
AU  - Jamwal VS
FAU - Patel, Dev Dutt
AU  - Patel DD
FAU - Gupta, Ashutosh Kumar
AU  - Gupta AK
FAU - Singh, Praveen Kumar
AU  - Singh PK
FAU - Javed, Saleem
AU  - Javed S
FAU - Kumar, Raj
AU  - Kumar R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130613
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Antioxidants)
RN  - 0 (Benzoquinones)
RN  - 0 (Glucosides)
RN  - 0 (Radiation-Protective Agents)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Bacillus/chemistry
MH  - Benzoquinones/isolation & purification/*pharmacology
MH  - Catalase/metabolism
MH  - Gamma Rays/*adverse effects
MH  - Glucosides/isolation & purification/*pharmacology
MH  - Glutathione/metabolism
MH  - Glutathione Transferase/metabolism
MH  - Liver/drug effects/enzymology/metabolism/*radiation effects
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Oxidative Stress/drug effects
MH  - Radiation-Protective Agents/*pharmacology
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - GSH
OT  - antioxidant
OT  - catalase
OT  - glutathione-S-transferase
OT  - radioprotection
OT  - superoxide dismutase
EDAT- 2013/06/15 06:00
MHDA- 2015/04/04 06:00
CRDT- 2013/06/15 06:00
PHST- 2012/11/10 00:00 [received]
PHST- 2013/05/08 00:00 [revised]
PHST- 2013/05/12 00:00 [accepted]
PHST- 2013/06/15 06:00 [entrez]
PHST- 2013/06/15 06:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
AID - 10.1002/tox.21877 [doi]
PST - ppublish
SO  - Environ Toxicol. 2014 Dec;29(12):1471-8. doi: 10.1002/tox.21877. Epub 2013 Jun 
      13.