PMID- 23766486
OWN - NLM
STAT- MEDLINE
DCOM- 20140423
LR  - 20131017
IS  - 1460-2091 (Electronic)
IS  - 0305-7453 (Linking)
VI  - 68
IP  - 11
DP  - 2013 Nov
TI  - Clinical features of patients with infections caused by Candida guilliermondii 
      and Candida fermentati and antifungal susceptibility of the isolates at a medical 
      centre in Taiwan, 2001-10.
PG  - 2632-5
LID - 10.1093/jac/dkt214 [doi]
AB  - OBJECTIVES: This study was intended to analyse the clinical characteristics and 
      outcomes of patients with infections due to Candida guilliermondii complex and 
      evaluate in vitro susceptibilities of the isolates. METHODS: We searched the 
      Mycology Database of the National Taiwan University Hospital and identified 
      patients with infections due to C. guilliermondii complex from 2001 to 2010. 
      Isolates were identified to species level by two yeast identification systems and 
      restriction fragment length polymorphism of the riboflavin synthetase gene. MICs 
      of nine antifungal agents were determined using the Sensititre YeastOne system 
      (Trek Diagnostic Systems) and were interpreted by breakpoints (BPs) for three 
      echinocandins and epidemiological cut-off values (ECVs) for the other agents. 
      RESULTS: Fifty-two patients with infections due to C. guilliermondii complex were 
      evaluated. The majority (90%, n = 47) of the isolates were C. guilliermondii, 
      followed by Candida fermentati (10%, n = 5). Among them, 42 (81%) were isolated 
      from blood cultures. Among the 52 patients, 27 (52%) had underlying malignancy 
      and 15 (29%) had undergone abdominal surgery. The 30 day mortality rates among 
      patients with C. guilliermondii and C. fermentati infections were 45% and 60%, 
      respectively. Among C. guilliermondii isolates, 98%, 100% and 98% were 
      susceptible to caspofungin, micafungin and anidulafungin, respectively, by BPs. 
      Nearly all (96%-100%) C. guilliermondii isolates belonged to wild-type for the 
      other agents by ECVs. All five C. fermentati were susceptible to three 
      echinocandins and belonged to wild-type for the other agents. CONCLUSIONS: The 
      currently used antifungal agents exhibited good in vitro activities against C. 
      guilliermondii complex isolates.
FAU - Chen, Chien-Yuan
AU  - Chen CY
AD  - Department of Internal Medicine, National Taiwan University Hospital, National 
      Taiwan University College of Medicine, Taipei, Taiwan.
FAU - Huang, Shang-Yi
AU  - Huang SY
FAU - Tang, Jih-Luh
AU  - Tang JL
FAU - Tsay, Woei
AU  - Tsay W
FAU - Yao, Ming
AU  - Yao M
FAU - Ko, Bo-Sheng
AU  - Ko BS
FAU - Chou, Wen-Chien
AU  - Chou WC
FAU - Tien, Hwei-Fang
AU  - Tien HF
FAU - Hsueh, Po-Ren
AU  - Hsueh PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130613
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antifungal Agents/*pharmacology
MH  - Candida/*classification/*drug effects/isolation & purification
MH  - Candidiasis/*microbiology/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hospitals, University
MH  - Humans
MH  - Infant
MH  - Male
MH  - Microbial Sensitivity Tests
MH  - Middle Aged
MH  - Mycological Typing Techniques
MH  - Polymorphism, Restriction Fragment Length
MH  - Retrospective Studies
MH  - Taiwan
MH  - Young Adult
OTO - NOTNLM
OT  - candidaemia
OT  - drug resistance
OT  - in vitro antifungal susceptibility
OT  - malignancy
OT  - outcomes
EDAT- 2013/06/15 06:00
MHDA- 2014/04/24 06:00
CRDT- 2013/06/15 06:00
PHST- 2013/06/15 06:00 [entrez]
PHST- 2013/06/15 06:00 [pubmed]
PHST- 2014/04/24 06:00 [medline]
AID - dkt214 [pii]
AID - 10.1093/jac/dkt214 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2013 Nov;68(11):2632-5. doi: 10.1093/jac/dkt214. Epub 
      2013 Jun 13.