PMID- 23766863
OWN - NLM
STAT- MEDLINE
DCOM- 20140813
LR  - 20211021
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2013
DP  - 2013
TI  - Effect of Clonidine (an antihypertensive drug) treatment on oxidative stress 
      markers in the heart of spontaneously hypertensive rats.
PG  - 927214
LID - 10.1155/2013/927214 [doi]
LID - 927214
AB  - Hypertension is a risk factor for several cardiovascular diseases and oxidative 
      stress suggested to be involved in the pathophysiology. Antihypertensive drug 
      Clonidine action in ameliorating oxidative stress was not well studied. 
      Therefore, this study investigate the effect of Clonidine on oxidative stress 
      markers and nitric oxide (NO) in SHR and nitric oxide synthase inhibitor, 
      N-nitro-L-arginine methyl ester (L-NAME) administered SHR. Male rats were divided 
      into four groups [SHR, SHR+Clonidine (SHR-C), SHR+L-NAME, 
      SHR+Clonidine+L-NAME(SHRC+L-NAME)]. Rats (SHRC) were administered with Clonidine 
      (0.5 mg kg(-1) day(-1)) from 4 weeks to 28 weeks in drinking water and L-NAME (25 
      mg kg(-1) day(-1)) from 16 weeks to 28 weeks to SHRC+L-NAME. Systolic blood 
      pressure (SBP) was measured. At the end of 28 weeks, all rats were sacrificed and 
      in their heart homogenate, oxidative stress parameters and NO was assessed. 
      Clonidine treatment significantly enhanced the total antioxidant status (TAS) (P 
      < 0.001) and reduced the thibarbituric acid reactive substances (TBARS) (P < 
      0.001) and protein carbonyl content (PCO) (P < 0.05). These data suggest that 
      oxidative stress is involved in the hypertensive organ damage and Clonidine not 
      only lowers the SBP but also ameliorated the oxidative stress in the heart of SHR 
      and SHR+L-NAME.
FAU - Nik Yusoff, Nik Syamimi
AU  - Nik Yusoff NS
AD  - Department of Chemical Pathology, School of Medical Sciences, Universiti Sains 
      Malaysia, Kubang Kerian, Kelantan, Malaysia.
FAU - Mustapha, Zulkarnain
AU  - Mustapha Z
FAU - Govindasamy, Chandran
AU  - Govindasamy C
FAU - Sirajudeen, K N S
AU  - Sirajudeen KN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130516
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - MN3L5RMN02 (Clonidine)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/administration & dosage/*pharmacology/therapeutic use
MH  - Antioxidants/metabolism
MH  - Biomarkers/*metabolism
MH  - Blood Pressure/drug effects
MH  - Clonidine/administration & dosage/*pharmacology/*therapeutic use
MH  - Heart/*drug effects/physiopathology
MH  - Hypertension/*drug therapy/physiopathology
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/administration & dosage/pharmacology/therapeutic 
      use
MH  - Nitric Oxide/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Protein Carbonylation/drug effects
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Thiobarbituric Acid Reactive Substances/metabolism
PMC - PMC3671561
EDAT- 2013/06/15 06:00
MHDA- 2014/08/15 06:00
PMCR- 2013/05/16
CRDT- 2013/06/15 06:00
PHST- 2013/02/09 00:00 [received]
PHST- 2013/04/04 00:00 [accepted]
PHST- 2013/06/15 06:00 [entrez]
PHST- 2013/06/15 06:00 [pubmed]
PHST- 2014/08/15 06:00 [medline]
PHST- 2013/05/16 00:00 [pmc-release]
AID - 10.1155/2013/927214 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2013;2013:927214. doi: 10.1155/2013/927214. Epub 2013 May 
      16.