PMID- 23767933
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20221207
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 14
DP  - 2013 Jun 17
TI  - Lack of associations between two previously identified susceptible single 
      nucleotide polymorphisms of interleukin-23 receptor gene and ankylosing 
      spondylitis: a replication study in a Chinese Han population.
PG  - 190
LID - 10.1186/1471-2474-14-190 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA)-B27 gene is considered to be a 
      major gene associated with predisposition to ankylosing spondylitis (AS); 
      however, studies have demonstrated that non-HLA-B27 genes also contribute 
      substantially to the susceptibility to AS. Two single nucleotide polymorphisms 
      (SNPs), rs1004819 and rs10889677, of the interleukin-23 receptor (IL-23R) gene 
      have been shown to be associated with AS susceptibility in European populations. 
      However, ethnicity factors contribute to population splitting and genetic 
      variation, and ethnic-specific genetic association studies are needed to validate 
      these associations in patients from different ethnic backgrounds. This study 
      therefore aimed to replicate the associations between these two SNPs and AS 
      susceptibility in a Chinese Han population. METHODS: A total of 195 AS patients 
      and 203 normal controls were recruited in this study. Two IL-23R gene SNPs, 
      rs1004819 and rs10889677 were selected. Genotyping was performed in all subjects 
      using the TaqMan probe method. Genotype and allele frequencies were compared 
      between AS patients and normal controls by chi2 tests. RESULTS: There were no 
      significant differences in either the genotype frequencies (TT 36.4%, TC 48.7% 
      and CC 14.9% in AS patients; TT 35.0%, TC 50.0% and CC 15.0% in normal controls) 
      or allele frequencies (T 60.8% and C 39.2% in AS patients; T 60.0% and C 40.0% in 
      normal controls) of rs1004819 between AS patients and normal controls (P > 0.05). 
      In addition, both the genotype frequencies (AA 51.3%, AC 43.1% and CC 5.6% in AS 
      patients; AA 57.6%, AC 35.5% and CC 6.9% in normal controls) and allele 
      frequencies (A 72.8% and C 27.2% in AS patients; A 75.4% and C 24.6% in normal 
      controls) of rs10889677 were also comparable between AS patients and normal 
      controls (P > 0.05). CONCLUSIONS: This study found no evidence for an association 
      between either of the two previously identified AS-susceptibility IL-23R SNPs 
      (rs1004819 and rs10889677) and onset of AS, indicating a possible difference in 
      pathogenesis of AS between Chinese and European patients.
FAU - Qian, Bang-ping
AU  - Qian BP
AD  - Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, Nanjing, China.
FAU - Jiang, Jun
AU  - Jiang J
FAU - Ji, Ming-liang
AU  - Ji ML
FAU - Wang, Bin
AU  - Wang B
FAU - Yu, Yang
AU  - Yu Y
FAU - Qiu, Yong
AU  - Qiu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130617
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - 0 (IL23R protein, human)
RN  - 0 (Receptors, Interleukin)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Ethnicity/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin/*genetics
MH  - Spondylitis, Ankylosing/ethnology/*genetics
MH  - Young Adult
PMC - PMC3706219
EDAT- 2013/06/19 06:00
MHDA- 2013/10/23 06:00
PMCR- 2013/06/17
CRDT- 2013/06/18 06:00
PHST- 2012/11/07 00:00 [received]
PHST- 2013/06/10 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
PHST- 2013/06/17 00:00 [pmc-release]
AID - 1471-2474-14-190 [pii]
AID - 10.1186/1471-2474-14-190 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2013 Jun 17;14:190. doi: 10.1186/1471-2474-14-190.