PMID- 23768014
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20151119
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 133
IP  - 8
DP  - 2013 Aug
TI  - A high nuclear nm23-H1 expression is associated with a better prognosis in 
      elderly patients with laryngeal carcinoma.
PG  - 874-80
LID - 10.3109/00016489.2013.777159 [doi]
AB  - CONCLUSIONS: Nuclear nm23-H1 expression may be useful in identifying elderly 
      patients operated for laryngeal squamous cell carcinoma (LSCC) at higher risk of 
      recurrence. Further studies are needed to clarify the biological role of nm23-H1 
      in elderly patients with LSCC and to determine how to restore nm23-H1 loss of 
      expression/function. OBJECTIVES: Nowadays more than 50% of cancer cases are 
      elderly patients and this percentage is expected to be 70% by 2030. Despite 
      advances in LSCC diagnosis and treatment, patient survival has not improved in 
      the last two decades. Novel, effective strategies should rely also on 
      receptor-mediated LSCC-targeted therapy. nm23-H1 protein is related to the tumor 
      cells' metastatic potential, and low nm23-H1 expression in carcinomas often 
      correlates with a poor prognosis. METHODS: Immunohistochemistry and image 
      analysis were used to investigate the prognostic value of nm23-H1 expression and 
      subcellular localization in a series of 54 elderly patients consecutively 
      undergoing primary surgery for LSCC. RESULTS: On univariate analysis, the disease 
      recurrence rate correlated inversely with nuclear nm23-H1 expression (p = 0.014), 
      and disease-free survival (DFS) was longer in patients whose nuclear nm23-H1 
      levels were >/=2.0% (p = 0.022). On multivariate analysis, nuclear nm23-H1 
      expression (hazard ratio (HR) 2.77, p = 0.022) and N stage (HR 3.49, p = 0.007) 
      were prognostically significant in terms of DFS.
FAU - Lionello, Marco
AU  - Lionello M
AD  - Department of Neurosciences, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Blandamura, Stella
AU  - Blandamura S
FAU - Lovato, Andrea
AU  - Lovato A
FAU - Franchella, Sebastiano
AU  - Franchella S
FAU - Giacomelli, Luciano
AU  - Giacomelli L
FAU - Ottaviano, Giancarlo
AU  - Ottaviano G
FAU - Stellini, Edoardo
AU  - Stellini E
FAU - Staffieri, Alberto
AU  - Staffieri A
FAU - Marioni, Gino
AU  - Marioni G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130614
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (NM23 Nucleoside Diphosphate Kinases)
RN  - EC 2.7.4.6 (NME1 protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*biosynthesis
MH  - Carcinoma/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Multivariate Analysis
MH  - NM23 Nucleoside Diphosphate Kinases/*biosynthesis/metabolism
MH  - Neoplasm Recurrence, Local/*metabolism
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2013/06/19 06:00
MHDA- 2014/01/23 06:00
CRDT- 2013/06/18 06:00
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.3109/00016489.2013.777159 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2013 Aug;133(8):874-80. doi: 10.3109/00016489.2013.777159. Epub 
      2013 Jun 14.