PMID- 23769397
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20151119
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 34
IP  - 11
DP  - 2013 Nov
TI  - BDNF Val66Met, Abeta amyloid, and cognitive decline in preclinical Alzheimer's 
      disease.
PG  - 2457-64
LID - S0197-4580(13)00204-2 [pii]
LID - 10.1016/j.neurobiolaging.2013.05.006 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously 
      been implicated in Alzheimer's disease (AD)-related cognitive impairment. We 
      aimed to determine the relationship between BDNF Val66Met and beta-amyloid (Abeta) 
      on cognitive decline, hippocampal atrophy, and Abeta accumulation over 36 months in 
      165 healthy adults enrolled in the Australian Imaging, Biomarkers and Lifestyle 
      study. In healthy adults with high Abeta, Met carriers showed significant and 
      moderate-to-large declines in episodic memory, executive function, and language, 
      and greater hippocampal atrophy over 36 months, compared with Val/Val 
      homozygotes. BDNF Val66Met was not found to be related to rates of change in 
      cognition or hippocampal volume in healthy adults with low Abeta. BDNF Val66Met did 
      not relate to the amount of Abeta or to the rate of Abeta accumulation in either group. 
      High Abeta levels coupled with Met carriage may be useful prognostic markers of 
      accelerated cognitive decline and hippocampal degeneration in individuals in the 
      preclinical stage of AD.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Lim, Yen Ying
AU  - Lim YY
AD  - Mental Health Research Institute, The University of Melbourne, Parkville, 
      Victoria, Australia. y.lim@mhri.edu.au
FAU - Villemagne, Victor L
AU  - Villemagne VL
FAU - Laws, Simon M
AU  - Laws SM
FAU - Ames, David
AU  - Ames D
FAU - Pietrzak, Robert H
AU  - Pietrzak RH
FAU - Ellis, Kathryn A
AU  - Ellis KA
FAU - Harrington, Karra D
AU  - Harrington KD
FAU - Bourgeat, Pierrick
AU  - Bourgeat P
FAU - Salvado, Olivier
AU  - Salvado O
FAU - Darby, David
AU  - Darby D
FAU - Snyder, Peter J
AU  - Snyder PJ
FAU - Bush, Ashley I
AU  - Bush AI
FAU - Martins, Ralph N
AU  - Martins RN
FAU - Masters, Colin L
AU  - Masters CL
FAU - Rowe, Christopher C
AU  - Rowe CC
FAU - Nathan, Pradeep J
AU  - Nathan PJ
FAU - Maruff, Paul
AU  - Maruff P
CN  - Australian Imaging, Biomarkers and Lifestyle (AIBL) Research Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130612
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole)
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Aniline Compounds)
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Thiazoles)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/diagnosis
MH  - Amyloid beta-Peptides/*metabolism
MH  - Aniline Compounds
MH  - Apolipoprotein E4/genetics
MH  - Australia
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Cognition Disorders/etiology/genetics/metabolism
MH  - Female
MH  - Genotype
MH  - Hippocampus/metabolism/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory, Episodic
MH  - Methionine/*genetics
MH  - Neuropsychological Tests
MH  - Positron-Emission Tomography
MH  - Psychiatric Status Rating Scales
MH  - Thiazoles
MH  - Valine/*genetics
OTO - NOTNLM
OT  - Abeta accumulation
OT  - BDNF Val66Met
OT  - Cognitive decline
OT  - Healthy older adults
OT  - Hippocampal atrophy
OT  - Preclinical Alzheimer's disease
OT  - beta-Amyloid
EDAT- 2013/06/19 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/06/18 06:00
PHST- 2012/12/10 00:00 [received]
PHST- 2013/03/18 00:00 [revised]
PHST- 2013/05/06 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - S0197-4580(13)00204-2 [pii]
AID - 10.1016/j.neurobiolaging.2013.05.006 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2013 Nov;34(11):2457-64. doi: 
      10.1016/j.neurobiolaging.2013.05.006. Epub 2013 Jun 12.