PMID- 23769403
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20130617
IS  - 1875-2128 (Electronic)
IS  - 1875-2128 (Linking)
VI  - 106
IP  - 5
DP  - 2013 May
TI  - Initial French experience of percutaneous mitral valve repair with the MitraClip: 
      a multicentre national registry.
PG  - 287-94
LID - S1875-2136(13)00129-0 [pii]
LID - 10.1016/j.acvd.2013.03.059 [doi]
AB  - BACKGROUND: Percutaneous mitral valve repair (MVR) using the MitraClip((R)) is a 
      new option for severe mitral regurgitation (MR). AIM: To describe initial French 
      experience regarding short-term and mid-term safety and efficacy. METHODS: A 
      multicentre cohort reported experience of percutaneous MVR using the MitraClip((R)) 
      in French centres from December 2010 to September 2012. All patients were judged 
      inoperable or at high surgical risk. Short-term and mid-term safety and efficacy 
      results are presented. RESULTS: Sixty-two patients (72.7+/-11.4years; 71.7% men; 
      81.0% New York Heart Association [NYHA] class III or IV; logistic Euroscore 
      18.7+/-13.1%; 93.3% MR>/=grade 3; 73.8% secondary MR) underwent percutaneous MVR 
      using the MitraClip((R)) under general anaesthesia. Procedural success was 95.2% 
      (83.1% of patients received one clip; 16.9% received two clips). At discharge, 
      88.2% of implanted patients had a residual MR</=grade 2. Transthoracic 
      echocardiography showed a significant decrease in ejection fraction (39.9+/-14.8% 
      pre vs. 36.2+/-14.3% post), end-diastolic diameter (63.8+/-10.6mm vs. 61.4+/-12.3mm, 
      respectively) and systolic pulmonary pressure (52.1+/-13.9mmHg vs. 44.7+/-10.9mmHg, 
      respectively). The in-hospital mortality rate was 3.2%. The survival rate at 
      6-month follow-up was estimated at 83.1%, with 90.9% of patients in NYHA class I 
      or II and residual MR</=grade 2 in 80% of cases. CONCLUSION: This initial French 
      experience, despite being in its learning phase, showed promising results in 
      patients considered ineligible for surgery, as observed in more experienced 
      centres. Randomized studies are mandatory to confirm these preliminary data.
CI  - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.
FAU - Armoiry, Xavier
AU  - Armoiry X
AD  - Hospices Civils de Lyon, Delegation a la Recherche Clinique et a l'Innovation, 
      Cellule Innovation, quai des Celestins, 69000 Lyon, France.
FAU - Brochet, Eric
AU  - Brochet E
FAU - Lefevre, Thierry
AU  - Lefevre T
FAU - Guerin, Patrice
AU  - Guerin P
FAU - Dumonteil, Nicolas
AU  - Dumonteil N
FAU - Himbert, Dominique
AU  - Himbert D
FAU - Cormier, Bertrand
AU  - Cormier B
FAU - Piriou, Nicolas
AU  - Piriou N
FAU - Gautier, Mathieu
AU  - Gautier M
FAU - Messika-Zeitoun, David
AU  - Messika-Zeitoun D
FAU - Romano, Mauro
AU  - Romano M
FAU - Rioufol, Gilles
AU  - Rioufol G
FAU - Warin Fresse, Karine
AU  - Warin Fresse K
FAU - Boudou, Nicolas
AU  - Boudou N
FAU - Leclercq, Florence
AU  - Leclercq F
FAU - Bedossa, Marc
AU  - Bedossa M
FAU - Obadia, Jean-Francois
AU  - Obadia JF
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20130528
PL  - Netherlands
TA  - Arch Cardiovasc Dis
JT  - Archives of cardiovascular diseases
JID - 101465655
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anesthesia, General
MH  - Female
MH  - France
MH  - *Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/adverse effects/*instrumentation/mortality
MH  - Hospital Mortality
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/physiopathology/*surgery
MH  - Mitral Valve Annuloplasty/adverse effects/*instrumentation/mortality
MH  - Mitral Valve Insufficiency/mortality/physiopathology/*surgery
MH  - Prosthesis Design
MH  - Registries
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - *Surgical Instruments
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2013/06/19 06:00
MHDA- 2013/10/23 06:00
CRDT- 2013/06/18 06:00
PHST- 2012/12/07 00:00 [received]
PHST- 2013/03/04 00:00 [revised]
PHST- 2013/03/18 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
AID - S1875-2136(13)00129-0 [pii]
AID - 10.1016/j.acvd.2013.03.059 [doi]
PST - ppublish
SO  - Arch Cardiovasc Dis. 2013 May;106(5):287-94. doi: 10.1016/j.acvd.2013.03.059. 
      Epub 2013 May 28.