PMID- 23769609
OWN - NLM
STAT- MEDLINE
DCOM- 20140505
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 150
IP  - 2
DP  - 2013 Sep 5
TI  - Serum neurotrophic factors in adolescent depression: gender difference and 
      correlation with clinical severity.
PG  - 415-23
LID - S0165-0327(13)00334-0 [pii]
LID - 10.1016/j.jad.2013.04.033 [doi]
AB  - BACKGROUND: Brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), 
      neurotrophin-3 (NT-3) and glial cell line derived neurotrophic factor (GDNF) play 
      critical role in growth, differentiation, maintenance and synaptic plasticity in 
      neuronal systems which is more relevant in adolescence. The present study was 
      undertaken to verify the 'neurotrophin hypothesis' in adolescent depression by 
      (i) comparing serum concentrations of neurotrophic factors in depression patients 
      and healthy control, and (ii) analyzing correlations between clinical severity 
      and serum neurotrophin levels. METHODS: Eighty four adolescent (aged 13-18 years) 
      depressed patients (56 males; 60 medication free/naive) and 64 healthy controls 
      (39 males) were recruited. Severity of depression was measured by Beck's 
      depression inventory, and anxiety by state-trait anxiety inventory. Measurement 
      of serum neurotrophins was done by ELISA. RESULTS: Adolescents with depression 
      had significantly lower levels of BDNF: mean diff. (95% C.I.): 2093.9 (1074.0, 
      3113.9), NGF: 813.3 (343.1, 1283.6) and GDNF: 158.8 (77.2, 240.4) compared to 
      controls. On gender based analysis female controls had significantly increased 
      trait anxiety scores [-1.1 (-1.8, -0.1)], as compared to control males. In the 
      patient group, female patients had far lower level of NGF: 919.6 (210.9, 1628.3) 
      and NT-3: 1288.8 (145.4, 2432.3) compared to male. BDI-II score showed a 
      statistically significant (p<0.01) negative correlation with all four 
      neurotrophins in male patients while in female patients such negative correlation 
      was observed only with NGF and GDNF (p<0.01). LIMITATIONS: The study is 
      cross-sectional from a tertiary care hospital. CONCLUSION: The novelty of the 
      study lies in its large number of exclusively adolescent depression patients 
      showing significant reduction of BDNF, NGF and GDNF serum levels as compared to 
      controls. A gender bias with much reduction in female has also been recorded.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Pallavi, Pooja
AU  - Pallavi P
AD  - Department of Laboratory Medicine, All India Institute of Medical Sciences, 
      Ansari Nagar 110029, New Delhi, India.
FAU - Sagar, Rajesh
AU  - Sagar R
FAU - Mehta, Manju
AU  - Mehta M
FAU - Sharma, Subhadra
AU  - Sharma S
FAU - Subramanium, Arulselvi
AU  - Subramanium A
FAU - Shamshi, Farah
AU  - Shamshi F
FAU - Sengupta, Utpal
AU  - Sengupta U
FAU - Qadri, Rizwana
AU  - Qadri R
FAU - Pandey, Ravindra M
AU  - Pandey RM
FAU - Mukhopadhyay, Asok K
AU  - Mukhopadhyay AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130612
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Brain-Derived Neurotrophic Factor/*blood/metabolism
MH  - Case-Control Studies
MH  - Depression/*blood
MH  - Female
MH  - Glial Cell Line-Derived Neurotrophic Factor/*blood
MH  - Humans
MH  - Male
MH  - Nerve Growth Factor/blood
MH  - Neurotrophin 3/*blood
MH  - Personality Inventory
MH  - Sex Factors
OTO - NOTNLM
OT  - Adolescent depression
OT  - Clinical correlation
OT  - Gender difference
OT  - Neurotrophic factor
EDAT- 2013/06/19 06:00
MHDA- 2014/05/06 06:00
CRDT- 2013/06/18 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2013/04/25 00:00 [revised]
PHST- 2013/04/26 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/05/06 06:00 [medline]
AID - S0165-0327(13)00334-0 [pii]
AID - 10.1016/j.jad.2013.04.033 [doi]
PST - ppublish
SO  - J Affect Disord. 2013 Sep 5;150(2):415-23. doi: 10.1016/j.jad.2013.04.033. Epub 
      2013 Jun 12.