PMID- 23769690
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20151119
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 119
DP  - 2013 Jul 2
TI  - Vitamin E prevents high-fat high-carbohydrates diet-induced memory impairment: 
      the role of oxidative stress.
PG  - 72-8
LID - S0031-9384(13)00197-2 [pii]
LID - 10.1016/j.physbeh.2013.06.011 [doi]
AB  - Memory and learning are impaired by imbalanced diet consumption. High-fat 
      high-carbohydrate diet (HFCD) induces oxidative stress, which results in neuronal 
      damage and interference with synaptic transmission; hence, a decline in cognitive 
      function. Vitamin E is a fat soluble antioxidant that is believed to have 
      positive effects on learning and memory. In this study, we tested the hypothesis 
      that chronic administration of vitamin E prevents learning and memory impairment 
      induced by HFCD. In addition, possible molecular targets for HFCD, and vitamin E 
      that lead to cognitive effects were examined. Vitamin E and/or HFCD were 
      concurrently administered to animals for 6 weeks. Thereafter, behavioral studies 
      were conducted to test the spatial learning and memory using radial arm water 
      maze (RAWM). Additionally, brain derived neurotrophic factor (BDNF) level and 
      antioxidant markers were assessed in the hippocampus. The results of this project 
      revealed that HFCD impairs both short-term and long-term memories (p<0.05). The 
      administration of vitamin E prevented the memory impairment induced by HFCD 
      consumption (p<0.05). The consumption of HFCD reduced activities of hippocampal 
      superoxide dismutase (SOD) and catalase (p<0.05); whereas the levels of 
      thiobarbituric acid reactive substances (TBARS) and oxidized glutathione (GSSG) 
      were elevated (p<0.05). The administration of vitamin E normalized the effect of 
      HFCD on the oxidative stress markers. None of the treatments induced changes in 
      the levels of BDNF or glutathione peroxidase (GPx). In conclusion, HFCD induces 
      memory impairment, and the administration of vitamin E prevented this impairment 
      probably through normalizing antioxidant mechanisms in the hippocampus.
CI  - Copyright (c) 2013. Published by Elsevier Inc.
FAU - Alzoubi, Karem H
AU  - Alzoubi KH
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan. khalzoubi@just.edu.jo
FAU - Khabour, Omar F
AU  - Khabour OF
FAU - Salah, Heba A
AU  - Salah HA
FAU - Hasan, Zuheir
AU  - Hasan Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130613
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 1406-18-4 (Vitamin E)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism/*pharmacology/therapeutic use
MH  - Biomarkers/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dietary Carbohydrates/*adverse effects
MH  - Dietary Fats/*adverse effects
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/chemically induced/*drug therapy/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Vitamin E/*pharmacology/therapeutic use
OTO - NOTNLM
OT  - Diet
OT  - High-carbohydrate
OT  - High-fat
OT  - Hippocampus
OT  - Learning
OT  - Maze
OT  - Memory
OT  - Oxidative stress
OT  - Vitamin E
EDAT- 2013/06/19 06:00
MHDA- 2014/04/05 06:00
CRDT- 2013/06/18 06:00
PHST- 2013/03/02 00:00 [received]
PHST- 2013/06/05 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
AID - S0031-9384(13)00197-2 [pii]
AID - 10.1016/j.physbeh.2013.06.011 [doi]
PST - ppublish
SO  - Physiol Behav. 2013 Jul 2;119:72-8. doi: 10.1016/j.physbeh.2013.06.011. Epub 2013 
      Jun 13.