PMID- 23769761
OWN - NLM
STAT- MEDLINE
DCOM- 20140327
LR  - 20171116
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 24
IP  - 10
DP  - 2013 Oct
TI  - Dietary fish oil reduces the acute inflammatory response and enhances resolution 
      of antigen-induced peritonitis.
PG  - 1758-65
LID - S0955-2863(13)00076-4 [pii]
LID - 10.1016/j.jnutbio.2013.03.005 [doi]
AB  - Dietary n-3 polyunsaturated fatty acids (PUFA) influence the inductive phase of 
      inflammation but less is known about their effects on the resolution phase. This 
      study examined the effects of dietary fish oil on induction and resolution of 
      antigen-induced inflammation in mice. Mice were fed a control diet with or 
      without 2.8% fish oil, immunized twice with methylated BSA (mBSA) and 
      inflammation induced by intraperitoneal injection of mBSA. Prior to and at 
      different time points after mBSA administration, peritoneal cells were analyzed 
      and expression of surface molecules determined by flow cytometry. Concentration 
      of chemokines, cytokines and soluble cytokine receptors was determined by ELISA. 
      Mice fed the fish oil diet had fewer peritoneal neutrophils, shorter resolution 
      interval and lower levels of pro-inflammatory cytokines and chemokines than mice 
      fed the control diet. In mice fed the fish oil diet there was an early peak in 
      peritoneal levels of the immunosuppressive molecules sIL-6R and TGF-beta, that was 
      not seen in mice fed the control diet. In the resolution phase, peritoneal 
      macrophages from mice fed the fish oil diet expressed more of the atypical 
      chemokine receptor D6 and peritoneal TGF-beta levels were higher than that in mice 
      fed the control diet. Furthermore, in the late-resolution phase there were more 
      peritoneal eosinophils and macrophages in mice fed the fish oil diet than in mice 
      fed the control diet. These results demonstrate a suppressive effect of n-3 PUFA 
      on the inductive phase of inflammation and indicate an enhancing effect of n-3 
      PUFA on resolution of inflammation.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Tomasdottir, Valgerdur
AU  - Tomasdottir V
AD  - Department of Biochemistry and Molecular Biology, Biomedical Center, University 
      of Iceland, 101 Reykjavik, Iceland; Center of Rheumatology Research and 
      Department of Immunology, Landspitali - The University Hospital of Iceland, 
      Reykjavik, Iceland.
FAU - Vikingsson, Arnor
AU  - Vikingsson A
FAU - Freysdottir, Jona
AU  - Freysdottir J
FAU - Hardardottir, Ingibjorg
AU  - Hardardottir I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130613
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Ccl11 protein, mouse)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Cxcl1 protein, mouse)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fish Oils)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Interleukin-6)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (interleukin-6, mouse)
RN  - 0 (methylated bovine serum albumin)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - 27432CM55Q (Serum Albumin, Bovine)
SB  - IM
MH  - Animals
MH  - Chemokine CCL11/drug effects
MH  - Chemokine CXCL1/drug effects
MH  - Dietary Fats, Unsaturated/*therapeutic use
MH  - Fatty Acids, Omega-3/*therapeutic use
MH  - Female
MH  - Fish Oils/*therapeutic use
MH  - Granulocyte Colony-Stimulating Factor/drug effects
MH  - Inflammation/prevention & control
MH  - Interleukin-6/metabolism
MH  - Macrophages, Peritoneal/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Peritonitis/diet therapy/immunology/*prevention & control
MH  - Receptors, Interleukin-6/drug effects
MH  - Serum Albumin, Bovine/immunology
MH  - Transforming Growth Factor beta/drug effects
OTO - NOTNLM
OT  - Antigen-induced inflammation
OT  - C
OT  - C-reactive protein
OT  - CRP
OT  - DHA
OT  - EPA
OT  - Eosinophils
OT  - FO
OT  - Fish oil
OT  - G-CSF
OT  - IL
OT  - MFI
OT  - Macrophages
OT  - NK cells
OT  - PBS
OT  - PDs
OT  - PUFA
OT  - R(i)
OT  - Rvs
OT  - SEM
OT  - control
OT  - docosahexaenoic acid
OT  - eicosapentaenoic acid
OT  - fish oil
OT  - granulocyte colony-stimulating factor
OT  - i.p
OT  - interleukin
OT  - intraperitoneal
OT  - mBSA
OT  - mean fluorescence intensity
OT  - methylated BSA
OT  - natural killer cells
OT  - phosphate buffered saline
OT  - polyunsaturated fatty acids
OT  - protectins
OT  - resolution interval
OT  - resolvins
OT  - standard error of the mean
EDAT- 2013/06/19 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/06/18 06:00
PHST- 2012/12/14 00:00 [received]
PHST- 2013/03/02 00:00 [revised]
PHST- 2013/03/22 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - S0955-2863(13)00076-4 [pii]
AID - 10.1016/j.jnutbio.2013.03.005 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2013 Oct;24(10):1758-65. doi: 10.1016/j.jnutbio.2013.03.005. Epub 
      2013 Jun 13.