PMID- 23769880
OWN - NLM
STAT- MEDLINE
DCOM- 20140604
LR  - 20190117
IS  - 1728-7731 (Electronic)
IS  - 1726-4901 (Linking)
VI  - 76
IP  - 8
DP  - 2013 Aug
TI  - Interleukin-18 and coronary artery lesions in patients with Kawasaki disease.
PG  - 438-45
LID - S1726-4901(13)00105-6 [pii]
LID - 10.1016/j.jcma.2013.04.005 [doi]
AB  - BACKGROUND: Interleukin-18 (IL-18) plays an important role in mediating cytokine 
      cascade leading to coronary artery lesions (CALs) in Kawasaki disease (KD). 
      However, our research suggested that the literature regarding IL-18 and KD is 
      limited. Consequently, this study aimed to evaluate the correlation between IL-18 
      and CALs in patients with KD. METHODS: In this prospective study of 14 children 
      with KD (seven without and seven with CALs in the acute phase), we obtained 
      patient measurements of a series of serum IL-18 levels in the acute, subacute, 
      and convalescent phases. Serum IL-18 levels were measured with a Bio-Plex 
      cytokine assay. Control samples were obtained from 18 febrile children with viral 
      infection. RESULTS: Compared with febrile controls, patients with acute-stage 
      CALs [postintravenous immunoglobulin (post-IVIG) period] had a significantly 
      higher IL-18 level (88.4 +/- 20.7 vs 56.0 +/- 35.0 pg/mL, p = 0.006). However, those 
      without acute-stage CALs (post-IVIG period) lacked similarly elevated IL-18 level 
      readings (62.0 +/- 40.6 vs 56.0 +/- 35.0 pg/mL, p = 0.762). The IL-18 level of 
      patients with acute-stage CALs did not decrease significantly until the 
      convalescent phase (97.4 +/- 55.8 vs 38.7 +/- 22.6 pg/mL, p = 0.018), but for those 
      without CALs, it decreased significantly in the subacute phase (60.2 +/- 37.4 vs 
      23.6 +/- 13.8 pg/mL, p = 0.018). In the subacute stage, there was a significant 
      difference of IL-18 level between patients with and without acute-stage CALs (p = 
      0.048). CONCLUSION: Our data show that IL-18 levels were elevated in the acute 
      phase of KD and might be related to the formation of CALs.
CI  - Copyright (c) 2013. Published by Elsevier B.V.
FAU - Weng, Ken-Pen
AU  - Weng KP
AD  - Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 
      ROC.
FAU - Hsieh, Kai-Sheng
AU  - Hsieh KS
FAU - Huang, Shih-Hui
AU  - Huang SH
FAU - Ou, Shan-F
AU  - Ou SF
FAU - Lai, Tsung-Jen
AU  - Lai TJ
FAU - Tang, Chia-Wan
AU  - Tang CW
FAU - Lin, Chu-Chuan
AU  - Lin CC
FAU - Ho, Tsyr-Yuh
AU  - Ho TY
FAU - Liou, Huei-Han
AU  - Liou HH
FAU - Ger, Luo-Ping
AU  - Ger LP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130613
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Interleukin-18)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Child, Preschool
MH  - Coronary Artery Disease/*etiology
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Infant
MH  - Infant, Newborn
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-18/blood/*physiology
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/complications/*immunology
MH  - Prospective Studies
OTO - NOTNLM
OT  - Kawasaki disease
OT  - coronary artery lesions
OT  - interleukin-18
EDAT- 2013/06/19 06:00
MHDA- 2014/06/05 06:00
CRDT- 2013/06/18 06:00
PHST- 2012/09/25 00:00 [received]
PHST- 2013/01/15 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/06/05 06:00 [medline]
AID - S1726-4901(13)00105-6 [pii]
AID - 10.1016/j.jcma.2013.04.005 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2013 Aug;76(8):438-45. doi: 10.1016/j.jcma.2013.04.005. Epub 
      2013 Jun 13.