PMID- 23769910
OWN - NLM
STAT- MEDLINE
DCOM- 20151020
LR  - 20141016
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 248
DP  - 2013 Sep 17
TI  - Two receptors are involved in the central functions of kynurenic acid under an 
      acute stress in neonatal chicks.
PG  - 194-200
LID - S0306-4522(13)00502-2 [pii]
LID - 10.1016/j.neuroscience.2013.06.005 [doi]
AB  - Intracerebroventricular (i.c.v.) injection of kynurenic acid (KYNA) had sedative 
      and hypnotic effects during stress in neonatal chicks. However, its mechanism has 
      not been clarified. KYNA is an endogenous antagonist of the alpha7 nicotinic 
      acetylcholine (alpha7nACh) receptor and N-methyl-d-aspartate (NMDA) receptor. 
      Therefore, this study clarified the mechanism of sedative and hypnotic effects of 
      KYNA in the brain during an acute stress. In Experiment 1, to investigate the 
      relationship between KYNA and the alpha7nACh receptor, KYNA was injected i.c.v. with 
      galantamine, an agonist of the allosteric potentiating site of the alpha7nACh 
      receptor. Galantamine did not attenuate the effect of KYNA, but higher levels of 
      galantamine caused harmful effects. In Experiment 2, the role of the NMDA 
      receptor was investigated using the NMDA receptor antagonist (+)-MK-801, d-serine 
      which has high affinity to a co-agonist glycine site at the NMDA receptors, NMDA 
      as the NMDA receptor agonist, and 2,3-pyridinedicarboxylic acid (QUIN), an 
      agonist of the NMDA receptor subgroup containing the subunits NR2A and NR2B. The 
      behavioral changes following KYNA were partially attenuated by QUIN alone. In 
      conclusion, we suggest that KYNA functioned via the simultaneous inhibition of 
      the alpha7nACh receptor and NMDA receptor subgroup containing the subunits NR2A and 
      NR2B.
CI  - Copyright (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Yoshida, J
AU  - Yoshida J
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Shigemura, A
AU  - Shigemura A
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Ogino, Y
AU  - Ogino Y
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Denbow, D M
AU  - Denbow DM
AD  - Department of Animal and Poultry Sciences, Virginia Tech University, Blacksburg, 
      VA 24061-0306, USA.
FAU - Furuse, M
AU  - Furuse M
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan. Electronic address: furuse@brs.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130613
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (alpha7 Nicotinic Acetylcholine Receptor)
RN  - 0D3Q044KCA (Galantamine)
RN  - H030S2S85J (Kynurenic Acid)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Chickens
MH  - Galantamine/pharmacology
MH  - Hypnotics and Sedatives/administration & dosage/*pharmacology
MH  - Infusions, Intraventricular
MH  - Kynurenic Acid/administration & dosage/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - Receptors, N-Methyl-D-Aspartate/agonists/antagonists & inhibitors/*physiology
MH  - Social Isolation
MH  - Stress, Physiological/*drug effects
MH  - Vocalization, Animal/drug effects
MH  - alpha7 Nicotinic Acetylcholine Receptor/agonists/antagonists & 
      inhibitors/*physiology
OTO - NOTNLM
OT  - NMDA receptors
OT  - chick
OT  - kynurenic acid
OT  - stress
OT  - alpha7nACh receptor
EDAT- 2013/06/19 06:00
MHDA- 2015/10/21 06:00
CRDT- 2013/06/18 06:00
PHST- 2013/04/26 00:00 [received]
PHST- 2013/05/30 00:00 [revised]
PHST- 2013/06/04 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2015/10/21 06:00 [medline]
AID - S0306-4522(13)00502-2 [pii]
AID - 10.1016/j.neuroscience.2013.06.005 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Sep 17;248:194-200. doi: 10.1016/j.neuroscience.2013.06.005. 
      Epub 2013 Jun 13.