PMID- 23770462
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20220408
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 379
IP  - 1-2
DP  - 2013 Oct 15
TI  - Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic 
      fatty liver disease.
PG  - 35-42
LID - S0303-7207(13)00240-2 [pii]
LID - 10.1016/j.mce.2013.06.002 [doi]
AB  - Alterations of hepatic mitochondrial function have been observed in states of 
      insulin resistance and non-alcoholic fatty liver disease (NAFLD). Patients with 
      overt type 2 diabetes mellitus (T2DM) can exhibit reduction in hepatic adenosine 
      triphosphate (ATP) synthesis and impaired repletion of their hepatic ATP stores 
      upon ATP depletion by fructose. Obesity and NAFLD may also associate with 
      impaired ATP recovery after ATP-depleting challenges and augmented oxidative 
      stress in the liver. On the other hand, patients with obesity or NAFLD can 
      present with upregulated hepatic anaplerotic and oxidative fluxes, including 
      beta-oxidation and tricarboxylic cycle activity. The present review focuses on the 
      methods and data on hepatic energy metabolism in various states of human insulin 
      resistance. We propose that the liver can adapt to increased lipid exposition by 
      greater lipid storing and oxidative capacity, resulting in increased oxidative 
      stress, which in turn could deteriorate hepatic mitochondrial function in chronic 
      insulin resistance and NAFLD.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Koliaki, Chrysi
AU  - Koliaki C
AD  - Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research, Heinrich Heine University, Dusseldorf, Germany. Electronic 
      address: Chryssi.Koliaki@ddz.uni-duesseldorf.de.
FAU - Roden, Michael
AU  - Roden M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130612
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Citric Acid Cycle/physiology
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Energy Metabolism/*physiology
MH  - Fatty Liver/*metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Liver/metabolism
MH  - Mitochondria, Liver/*metabolism
MH  - Non-alcoholic Fatty Liver Disease
MH  - Obesity/*metabolism
MH  - Oxidation-Reduction
MH  - Oxidative Stress/physiology
OTO - NOTNLM
OT  - Lipotoxicity
OT  - Mitochondrion
OT  - Non-alcoholic steatohepatitis (NASH)
OT  - Steatosis
EDAT- 2013/06/19 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/06/18 06:00
PHST- 2013/02/15 00:00 [received]
PHST- 2013/05/08 00:00 [revised]
PHST- 2013/06/03 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - S0303-7207(13)00240-2 [pii]
AID - 10.1016/j.mce.2013.06.002 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2013 Oct 15;379(1-2):35-42. doi: 10.1016/j.mce.2013.06.002. 
      Epub 2013 Jun 12.