PMID- 23770546
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20220309
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 461-462
DP  - 2013 Sep 1
TI  - Organohalogenated contaminants (OHCs) in human serum of mothers and children from 
      Pakistan with urban and rural residential settings.
PG  - 655-62
LID - S0048-9697(13)00587-1 [pii]
LID - 10.1016/j.scitotenv.2013.05.044 [doi]
AB  - This study aimed to provide first data on the concentrations of different classes 
      of organohalogenated contaminants (OHCs) in human serum from Pakistan, an area 
      with limited information on environmental pollution. Serum samples (N=85) were 
      collected from mothers (N=34; age ranged 23-51 years), their children (N=34; age 
      3-10 years) and general group (N=17; age 13-65 years) with rural and urban 
      residential settings. The concentrations of studied OHCs in serum decreased as 
      follows: organochlorinated pesticides (OCPs)>polychlorinated biphenyls 
      (PCBs)>polybrominated diphenyl ethers (PBDEs). Novel brominated flame retardants 
      (NBFRs) were not detected, except for 1,2-bis(2,4,6-tribromophenoxy)-ethane 
      (BTBPE)<0.2-8 ng/g lipid weight (lw). Low levels of HO-PCBs (<0.2-20 ng/g lw) 
      were detected, while HO-PBDEs were <0.2 ng/g lw.  summation operatorPCBs (2-105 ng/g lw) together 
      with  summation operatorPBDEs (0.2-6.7 ng/g lw) contributed ~5% of the total OHCs body burden. The 
      concentration(s) of major contributors (>80%) of OCPs ranged from <1-3645 ng/g lw 
      for 1,1'-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE), <1-445 ng/g lw for 
      beta-hexachlorocyclohexane (beta-HCH) and from 5 to 200 ng/g lw for pentachlorophenol 
      (PCP). p,p'-DDE, the major OHC, was significantly higher (p<0.05) in rural 
      children than in all other groups. In serum of rural children, the major OHCs 
      were significantly higher (p<0.05) than the mothers. The current study indicates 
      continuous exposure to humans with already regulated OHCs and highlights the need 
      for further monitoring of these OHCs in the region.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Ali, Nadeem
AU  - Ali N
AD  - Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, 
      Belgium.
FAU - Eqani, Syed Ali Musstjab Akber Shah
AU  - Eqani SA
FAU - Malik, Riffat Naseem
AU  - Malik RN
FAU - Neels, Hugo
AU  - Neels H
FAU - Covaci, Adrian
AU  - Covaci A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130612
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Hydrocarbons, Halogenated)
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Environmental Exposure/*analysis
MH  - Environmental Monitoring/methods/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Halogenated/*blood
MH  - Middle Aged
MH  - Mothers
MH  - Pakistan
MH  - Rural Population/statistics & numerical data
MH  - Statistics, Nonparametric
MH  - Urban Population/statistics & numerical data
OTO - NOTNLM
OT  - Children
OT  - Mothers
OT  - Organohalogenated contaminants (OHCs)
OT  - Pakistan
OT  - Serum
EDAT- 2013/06/19 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/06/18 06:00
PHST- 2013/02/11 00:00 [received]
PHST- 2013/05/15 00:00 [revised]
PHST- 2013/05/16 00:00 [accepted]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - S0048-9697(13)00587-1 [pii]
AID - 10.1016/j.scitotenv.2013.05.044 [doi]
PST - ppublish
SO  - Sci Total Environ. 2013 Sep 1;461-462:655-62. doi: 
      10.1016/j.scitotenv.2013.05.044. Epub 2013 Jun 12.