PMID- 23771490
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20231206
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 81
IP  - 3
DP  - 2013 Jul 16
TI  - Genetic risk variants in African Americans with multiple sclerosis.
PG  - 219-27
LID - 10.1212/WNL.0b013e31829bfe2f [doi]
AB  - OBJECTIVES: To assess the association of established multiple sclerosis (MS) risk 
      variants in 3,254 African Americans (1,162 cases and 2,092 controls). METHODS: 
      Human leukocyte antigen (HLA)-DRB1, HLA-DQB1, and HLA-A alleles were typed by 
      molecular techniques. Single nucleotide polymorphism (SNP) genotyping was 
      conducted for 76 MS-associated SNPs and 52 ancestry informative marker SNPs 
      selected throughout the genome. Self-declared ancestry was refined by principal 
      component analysis of the ancestry informative marker SNPs. An ancestry-adjusted 
      multivariate model was applied to assess genetic associations. RESULTS: The 
      following major histocompatibility complex risk alleles were replicated: 
      HLA-DRB1*15:01 (odds ratio [OR] = 2.02 [95% confidence interval: 1.54-2.63], p = 
      2.50e-07), HLA-DRB1*03:01 (OR = 1.58 [1.29-1.94], p = 1.11e-05), as well as 
      HLA-DRB1*04:05 (OR = 2.35 [1.26-4.37], p = 0.007) and the African-specific risk 
      allele of HLA-DRB1*15:03 (OR = 1.26 [1.05-1.51], p = 0.012). The protective 
      association of HLA-A*02:01 was confirmed (OR = 0.72 [0.55-0.93], p = 0.013). None 
      of the HLA-DQB1 alleles were associated with MS. Using a significance threshold 
      of p < 0.01, outside the major histocompatibility complex region, 8 MS SNPs were 
      also found to be associated with MS in African Americans. CONCLUSION: MS genetic 
      risk in African Americans only partially overlaps with that of Europeans and 
      could explain the difference of MS prevalence between populations.
FAU - Isobe, Noriko
AU  - Isobe N
AD  - Department of Neurology, School of Medicine, University of California, San 
      Francisco, CA, USA.
FAU - Gourraud, Pierre-Antoine
AU  - Gourraud PA
FAU - Harbo, Hanne F
AU  - Harbo HF
FAU - Caillier, Stacy J
AU  - Caillier SJ
FAU - Santaniello, Adam
AU  - Santaniello A
FAU - Khankhanian, Pouya
AU  - Khankhanian P
FAU - Maiers, Martin
AU  - Maiers M
FAU - Spellman, Stephen
AU  - Spellman S
FAU - Cereb, Nezih
AU  - Cereb N
FAU - Yang, SooYoung
AU  - Yang S
FAU - Pando, Marcelo J
AU  - Pando MJ
FAU - Piccio, Laura
AU  - Piccio L
FAU - Cross, Anne H
AU  - Cross AH
FAU - De Jager, Philip L
AU  - De Jager PL
FAU - Cree, Bruce A C
AU  - Cree BA
FAU - Hauser, Stephen L
AU  - Hauser SL
FAU - Oksenberg, Jorge R
AU  - Oksenberg JR
LA  - eng
GR  - HHSH234200637020C/PHS HHS/United States
GR  - R01NS046297/NS/NINDS NIH HHS/United States
GR  - R01NS076492/NS/NINDS NIH HHS/United States
GR  - RC2 GM093080/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20130614
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Black or African American/*genetics
MH  - Age of Onset
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-A Antigens/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/epidemiology/*genetics
MH  - *Polymorphism, Single Nucleotide
PMC - PMC3770164
EDAT- 2013/06/19 06:00
MHDA- 2013/09/24 06:00
PMCR- 2014/07/16
CRDT- 2013/06/18 06:00
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
PHST- 2014/07/16 00:00 [pmc-release]
AID - WNL.0b013e31829bfe2f [pii]
AID - WNL205204 [pii]
AID - 10.1212/WNL.0b013e31829bfe2f [doi]
PST - ppublish
SO  - Neurology. 2013 Jul 16;81(3):219-27. doi: 10.1212/WNL.0b013e31829bfe2f. Epub 2013 
      Jun 14.