PMID- 23771526
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140331
LR  - 20160512
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 405
IP  - 24
DP  - 2013 Sep
TI  - Rapid and simple method for determination of hexabromocyclododecanes and other 
      LC-MS-MS-amenable brominated flame retardants in fish.
PG  - 7829-39
LID - 10.1007/s00216-013-7076-x [doi]
AB  - In this study, a novel analytical approach for simultaneous determination of 
      hexabromocyclododecane isomers (HBCDs), tetrabromobisphenol A (TBBPA), three 
      brominated phenols, and four hydroxylated derivatives of polybrominated diphenyl 
      ethers (OH-PBDEs) was developed and validated for muscle tissue of both lean and 
      fatty fish. The rapid, simple, and high-throughput sample-preparation procedure 
      was based on acetonitrile extraction then purification by dispersive solid-phase 
      extraction (d-SPE) with a combination of C18 and primary-secondary amine (PSA) 
      sorbents. Ultra-high performance liquid chromatography (UHPLC) coupled to tandem 
      mass spectrometry (MS-MS) was used for identification and quantification of the 
      analytes. Method recovery for both matrices ranged from 80 to 115% with relative 
      standard deviations (RSDs) <13% for all analytes. Limits of quantification (LOQs) 
      were in the range 0.1-1 mug kg(-1) wet weight. The validated method was used for 
      analysis of brominated compounds in 32 fish and five bivalve samples collected 
      from different European markets within the monitoring survey organized in the 
      framework of the CONffIDENCE project. Of the 12 targeted analytes, only alpha-HBCD, 
      2,4-dibromophenol (2,4-DBP), and 2,4,6-tribromophenol (2,4,6-TBP) were quantified 
      in the samples. alpha-HBCD was found in six fish samples (herring and mackerel) in 
      the range of 0.8-2.5 mug kg(-1) wet weight. 2,4-DBP and 2,4,6-TBP were found in 
      three blue mussel samples in the range of 19.6-43.5 and 2.3-7.5 mug kg(-1) wet 
      weight, respectively.
FAU - Lankova, Darina
AU  - Lankova D
AD  - Department of Food Analysis and Nutrition, Faculty of Food and Biochemical 
      Technology, Institute of Chemical Technology, Prague, Technicka 3, 166 28, 
      Prague, Czech Republic.
FAU - Kockovska, Michala
AU  - Kockovska M
FAU - Lacina, Ondrej
AU  - Lacina O
FAU - Kalachova, Kamila
AU  - Kalachova K
FAU - Pulkrabova, Jana
AU  - Pulkrabova J
FAU - Hajslova, Jana
AU  - Hajslova J
LA  - eng
PT  - Journal Article
DEP - 20130616
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
EDAT- 2013/06/19 06:00
MHDA- 2013/06/19 06:01
CRDT- 2013/06/18 06:00
PHST- 2013/02/04 00:00 [received]
PHST- 2013/05/17 00:00 [accepted]
PHST- 2013/04/26 00:00 [revised]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2013/06/19 06:01 [medline]
AID - 10.1007/s00216-013-7076-x [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2013 Sep;405(24):7829-39. doi: 10.1007/s00216-013-7076-x. Epub 
      2013 Jun 16.