PMID- 23771673
OWN - NLM
STAT- MEDLINE
DCOM- 20140911
LR  - 20211021
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 33
IP  - 3
DP  - 2013 Jun
TI  - Changes in HIF-1alpha, VEGF, NGF and BDNF levels in cerebrospinal fluid and their 
      relationship with cognitive impairment in patients with cerebral infarction.
PG  - 433-437
LID - 10.1007/s11596-013-1137-4 [doi]
AB  - This study was carried out to investigate the role of intrinsic neuroprotective 
      mechanisms in the occurrence and development of vascular cognitive impairment 
      (VCI) with the goal of providing a target for the treatment and prevention of 
      VCI. Inpatients with proven cerebral infarction on cranial computed tomography 
      (CT) were recruited as the ischemic cerebrovascular diseases (ICVD) group, and 
      the patients with mixed stroke were excluded. In ICVD group, 12 patients were 
      diagnosed as having VCI and served as VCI group. Inpatients undergoing surgical 
      operation in our hospital were enrolled as control group. Double-antibody 
      sandwich enzyme-linked immunosorbent assay (ELISA) was employed to detect the 
      levels of hypoxia-inducible factor 1-alpha (HIF-1alpha), vascular endothelial growth 
      factor (VEGF), nerve growth factor (NGF) and brain-derived neurotrophic factor 
      (BDNF) in the cerebrospinal fluid of patients with ICVD. Associations between the 
      levels of these factors and the Mini-Mental State Examination (MMSE) score were 
      evaluated. In ICVD and VCI groups, the levels of HIF-1alpha and NGF in the 
      cerebrospinal fluid were markedly lower than those in control group (P=0.037 and 
      P=0.000; P=0.023 and P=0.005). In ICVD and VCI groups, the MMSE score was 
      negatively related to VEGF level in the cerebrospinal fluid (r=-0.327, P=0.021; 
      r=-0.585, P=0.046). In VCI group, HIF-1alpha level was correlated with NGF level 
      (r=0.589, P=0.044). HIF-1alpha and NGF are involved in ischemic and hypoxic cerebral 
      injury. The HIF signaling pathway plays an important role in intrinsic 
      neuroprotection. Upregulation and maintenance of HIF-1alpha and NGF expression may 
      attenuate VCI. Changes in VEGF levels are related to the occurrence and 
      development of cognitive impairment.
FAU - Ke, Xian-Jun
AU  - Ke XJ
AD  - Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, 
      China.
FAU - Zhang, Jun-Jian
AU  - Zhang JJ
AD  - Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, 
      China. wdsjkx@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130617
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Biomarkers/cerebrospinal fluid
MH  - Brain-Derived Neurotrophic Factor/*cerebrospinal fluid
MH  - Cerebral Infarction/*cerebrospinal fluid/complications/diagnosis
MH  - Cognition Disorders/*cerebrospinal fluid/complications/diagnosis
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*cerebrospinal fluid
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/*cerebrospinal fluid
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Vascular Endothelial Growth Factor A/*cerebrospinal fluid
EDAT- 2013/06/19 06:00
MHDA- 2014/09/12 06:00
CRDT- 2013/06/18 06:00
PHST- 2012/12/26 00:00 [received]
PHST- 2013/06/18 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/09/12 06:00 [medline]
AID - 10.1007/s11596-013-1137-4 [pii]
AID - 10.1007/s11596-013-1137-4 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):433-437. doi: 
      10.1007/s11596-013-1137-4. Epub 2013 Jun 17.