PMID- 23773060
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20220408
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 37
IP  - 12
DP  - 2013 Jun
TI  - Functional alteration patterns of default mode networks: comparisons of normal 
      aging, amnestic mild cognitive impairment and Alzheimer's disease.
PG  - 1916-24
LID - 10.1111/ejn.12177 [doi]
AB  - Most default mode network (DMN) studies in patients with amnestic mild cognitive 
      impairment (aMCI) and Alzheimer's disease (AD) are based on the comparison of 
      only two groups, namely patients and controls. Information derived from comparing 
      three groups, normal, aMCI and AD, simultaneously may lead us to better 
      understand the progression of dementia. The purpose of this study was to evaluate 
      functional connectivity of DMN in the continuum from normal through aMCI to AD. 
      Differences in functional connectivity were compared between the three groups 
      using independent component analysis. The relationship between functional 
      connectivity and disease progression was investigated using multiple regression 
      analysis with Mini-Mental State Examination (MMSE) scores. The results revealed 
      differences throughout the left posterior cingulate cortex (PCC), left middle 
      temporal gyrus (MTG), right middle frontal gyrus (MFG) and bilateral 
      parahippocampal gyrus (PHG). Both patients with aMCI and those with AD showed 
      decreased connectivity in the left PCC and left PHG compared with healthy 
      subjects. Furthermore, patients with AD also showed decreased connectivity in the 
      left MTG and right PHG. Increased functional connectivity was observed in the 
      right MFG of patients with AD compared with other groups. MMSE scores exhibited 
      significant positive and negative correlations with functional connectivity in 
      PCC, MTG and MFG regions. Taken together, increased functional connectivity in 
      the MFG for AD patients might compensate for the loss of function in the PCC and 
      MTG via compensatory mechanisms in corticocortical connections.
CI  - (c) 2013 Federation of European Neuroscience Societies and Blackwell Publishing 
      Ltd.
FAU - Cha, Jungho
AU  - Cha J
AD  - Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
FAU - Jo, Hang Joon
AU  - Jo HJ
FAU - Kim, Hee Jin
AU  - Kim HJ
FAU - Seo, Sang Won
AU  - Seo SW
FAU - Kim, Han-Soo
AU  - Kim HS
FAU - Yoon, Uicheul
AU  - Yoon U
FAU - Park, Hyunjin
AU  - Park H
FAU - Na, Duk L
AU  - Na DL
FAU - Lee, Jong-Min
AU  - Lee JM
LA  - eng
GR  - Z99 MH999999/Intramural NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Alzheimer Disease/*physiopathology
MH  - Amnesia/*physiopathology
MH  - Brain/physiology/*physiopathology
MH  - Cognitive Dysfunction/*physiopathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net
PMC - PMC3694739
MID - NIHMS443074
EDAT- 2013/06/19 06:00
MHDA- 2014/01/01 06:00
PMCR- 2014/06/01
CRDT- 2013/06/19 06:00
PHST- 2012/11/20 00:00 [received]
PHST- 2013/01/21 00:00 [revised]
PHST- 2013/01/30 00:00 [accepted]
PHST- 2013/06/19 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - 10.1111/ejn.12177 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2013 Jun;37(12):1916-24. doi: 10.1111/ejn.12177.