PMID- 23773352
OWN - NLM
STAT- MEDLINE
DCOM- 20130808
LR  - 20181203
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 68
IP  - 2
DP  - 2013 Mar-Apr
TI  - Frequency and outcomes of concomitant use of proton pump inhibitors and 
      clopidogrel after hospital discharge.
PG  - 113-5
LID - 10.2515/therapie/2013013 [doi]
AB  - OBJECTIVE: To assess the frequency of concomitant use of proton pump inhibitors 
      (PPI) in patients treated with clopidogrel, and the potential impact of this use 
      on cardiovascular events. METHOD: Three-month prospective observational study. 
      All patients taking clopidogrel who were admitted to the study hospital were 
      included in the study. They were split into categories based on whether they had 
      taken the drug concomitantly with PPI upon admission, upon discharge or during 
      follow-up, or if they had not taken the two drugs together at all. Any 
      post-discharge readmissions for cardiovascular events in the three months 
      following the original admission were also recorded. RESULTS: A total of 134 
      patients were included in the study. Only 26 patients (19,6%) did not take any 
      PPI. Among 14 patients (10.5%) readmitted because of a cardiovascular event, 13 
      were taking clopidogrel concomitantly with a PPI (not statistically significant). 
      Most of the readmitted patients presented other risk factors potentially related 
      with cardiovascular events. CONCLUSION: This study underlines a high concomitant 
      use of PPI with clopidogrel, with no evidence of an increasing risk of 
      readmission due to cardiovascular event potentially related to a drug-drug 
      interaction between these drugs. The study did not identify any readmission 
      related to a gastro-intestinal complication.
CI  - (c) 2013 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Mas-Morey, Pedro
AU  - Mas-Morey P
AD  - Pharmacy Department, Hospital Son Llatzer, Palma de Mallorca, Illes Balears, 
      Spain. p_mas_morey@hotmail.com
FAU - Calderon-Hernanz, Beatriz
AU  - Calderon-Hernanz B
FAU - Oliver-Noguera, Aina
AU  - Oliver-Noguera A
FAU - Ripoll-Vera, Tomas
AU  - Ripoll-Vera T
FAU - Vilanova-Bolto, Montserrat
AU  - Vilanova-Bolto M
LA  - eng
PT  - Journal Article
DEP - 20130618
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - OM90ZUW7M1 (Ticlopidine)
SB  - IM
MH  - Aged
MH  - Clopidogrel
MH  - Drug Interactions
MH  - Drug Utilization
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Discharge
MH  - Platelet Aggregation Inhibitors/adverse effects/*therapeutic use
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/adverse effects/*therapeutic use
MH  - Risk Factors
MH  - Ticlopidine/adverse effects/*analogs & derivatives/therapeutic use
MH  - Treatment Outcome
EDAT- 2013/06/19 06:00
MHDA- 2013/08/09 06:00
CRDT- 2013/06/19 06:00
PHST- 2012/04/05 00:00 [received]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/06/19 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2013/08/09 06:00 [medline]
AID - th132072 [pii]
AID - 10.2515/therapie/2013013 [doi]
PST - ppublish
SO  - Therapie. 2013 Mar-Apr;68(2):113-5. doi: 10.2515/therapie/2013013. Epub 2013 Jun 
      18.