PMID- 23773405 OWN - NLM STAT- MEDLINE DCOM- 20131106 LR - 20211021 IS - 1096-0341 (Electronic) IS - 0042-6822 (Print) IS - 0042-6822 (Linking) VI - 444 IP - 1-2 DP - 2013 Sep TI - Niakha virus: a novel member of the family Rhabdoviridae isolated from phlebotomine sandflies in Senegal. PG - 80-9 LID - S0042-6822(13)00316-4 [pii] LID - 10.1016/j.virol.2013.05.035 [doi] AB - Members of the family Rhabdoviridae have been assigned to eight genera but many remain unassigned. Rhabdoviruses have a remarkably diverse host range that includes terrestrial and marine animals, invertebrates and plants. Transmission of some rhabdoviruses often requires an arthropod vector, such as mosquitoes, midges, sandflies, ticks, aphids and leafhoppers, in which they replicate. Herein we characterize Niakha virus (NIAV), a previously uncharacterized rhabdovirus isolated from phebotomine sandflies in Senegal. Analysis of the 11,124 nt genome sequence indicates that it encodes the five common rhabdovirus proteins with alternative ORFs in the M, G and L genes. Phylogenetic analysis of the L protein indicate that NIAV's closest relative is Oak Vale rhabdovirus, although in this analysis NIAV is still so phylogenetically distinct that it might be classified as distinct from the eight currently recognized Rhabdoviridae genera. This observation highlights the vast, and yet not fully recognized diversity, of this family. CI - Copyright (c) 2013 Elsevier Inc. All rights reserved. FAU - Vasilakis, Nikos AU - Vasilakis N AD - Center for Biodefense and Emerging Infectious Diseases and Department of Pathology, Galveston, TX 77555-0609, USA. nivasila@utmb.edu FAU - Widen, Steven AU - Widen S FAU - Mayer, Sandra V AU - Mayer SV FAU - Seymour, Robert AU - Seymour R FAU - Wood, Thomas G AU - Wood TG FAU - Popov, Vsevolov AU - Popov V FAU - Guzman, Hilda AU - Guzman H FAU - Travassos da Rosa, Amelia P A AU - Travassos da Rosa AP FAU - Ghedin, Elodie AU - Ghedin E FAU - Holmes, Edward C AU - Holmes EC FAU - Walker, Peter J AU - Walker PJ FAU - Tesh, Robert B AU - Tesh RB LA - eng SI - GENBANK/KC585008 GR - HHSN272201000040I/AI/NIAID NIH HHS/United States GR - R01 AI010984/AI/NIAID NIH HHS/United States GR - HHSN27200004/D04/PHS HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20130614 PL - United States TA - Virology JT - Virology JID - 0110674 RN - 0 (RNA, Viral) SB - IM MH - Animals MH - Cluster Analysis MH - Molecular Sequence Data MH - Open Reading Frames MH - Phylogeny MH - Psychodidae/*virology MH - RNA, Viral/genetics MH - Rhabdoviridae/*classification/genetics/*isolation & purification MH - Senegal MH - Sequence Analysis, DNA PMC - PMC3755043 MID - NIHMS486352 OTO - NOTNLM OT - Complement fixation OT - Niakha virus (NIAV) OT - Phlebotomine sandflies OT - Rhabdoviridae OT - West Africa EDAT- 2013/06/19 06:00 MHDA- 2013/11/07 06:00 PMCR- 2014/09/01 CRDT- 2013/06/19 06:00 PHST- 2013/02/08 00:00 [received] PHST- 2013/05/21 00:00 [revised] PHST- 2013/05/22 00:00 [accepted] PHST- 2013/06/19 06:00 [entrez] PHST- 2013/06/19 06:00 [pubmed] PHST- 2013/11/07 06:00 [medline] PHST- 2014/09/01 00:00 [pmc-release] AID - S0042-6822(13)00316-4 [pii] AID - 10.1016/j.virol.2013.05.035 [doi] PST - ppublish SO - Virology. 2013 Sep;444(1-2):80-9. doi: 10.1016/j.virol.2013.05.035. Epub 2013 Jun 14.