PMID- 23773922
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20130715
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 148
IP  - 2
DP  - 2013 Aug
TI  - Tolerogenic dendritic cells as a therapy for treating lupus.
PG  - 237-45
LID - S1521-6616(13)00121-6 [pii]
LID - 10.1016/j.clim.2013.04.017 [doi]
AB  - Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that is 
      characterized by the over production of auto-antibodies against nuclear 
      components. Thus, SLE patients have increased morbidity and, mortality compared 
      to healthy individuals. Available therapies are not curative and are associated 
      with unwanted adverse effects. During the last few years, important advances in 
      immunology research have provided rheumatologists with new tools for designing 
      novel therapies for treating autoimmunity. However, the complex nature of SLE has 
      played a conflicting role, hindering breakthroughs in therapeutic development. 
      Nonetheless, new advances about SLE pathogenesis could open a fruitful line of 
      research. Dendritic cells (DCs) have been established as essential players in the 
      mechanisms underlying SLE, making them attractive therapeutic targets for 
      fine-tuning the immune system. In this review, we discuss the recent advances 
      made in revealing the mechanisms of SLE pathogenesis, with a focus on the use of 
      DCs as a target for therapy development.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Llanos, Carolina
AU  - Llanos C
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Inmunologia 
      Clinica y Reumatologia, Escuela de Medicina, Pontificia Universidad Catolica de 
      Chile, Chile. cllanos@med.puc.cl
FAU - Mackern-Oberti, Juan Pablo
AU  - Mackern-Oberti JP
FAU - Vega, Fabian
AU  - Vega F
FAU - Jacobelli, Sergio H
AU  - Jacobelli SH
FAU - Kalergis, Alexis M
AU  - Kalergis AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130512
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
SB  - IM
MH  - Dendritic Cells/*physiology
MH  - Humans
MH  - Immune Tolerance/*immunology/physiology
MH  - Immunity, Innate
MH  - Lupus Erythematosus, Systemic/*therapy
OTO - NOTNLM
OT  - Autoimmune diseases
OT  - Dendritic cells
OT  - Immune tolerance
OT  - Immunotherapy
OT  - Lupus
EDAT- 2013/06/19 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/06/19 06:00
PHST- 2013/03/05 00:00 [received]
PHST- 2013/04/03 00:00 [revised]
PHST- 2013/04/29 00:00 [accepted]
PHST- 2013/06/19 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - S1521-6616(13)00121-6 [pii]
AID - 10.1016/j.clim.2013.04.017 [doi]
PST - ppublish
SO  - Clin Immunol. 2013 Aug;148(2):237-45. doi: 10.1016/j.clim.2013.04.017. Epub 2013 
      May 12.