PMID- 23774996
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20151119
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 68
IP  - 1
DP  - 2013
TI  - Longitudinal changes in serum brain-derived neurotrophic factor in accident 
      survivors with posttraumatic stress disorder.
PG  - 44-50
LID - 10.1159/000350950 [doi]
AB  - BACKGROUND: This prospective cohort study investigated the serum levels of 
      brain-derived neurotrophic factor (BDNF), which mediates synaptic plasticity 
      crucial for fear memory extinction, in patients severely injured in motor vehicle 
      accidents (MVAs). METHOD: A nested, case-controlled study was conducted with 103 
      MVA survivors: 8 medication-naive patients who met the criteria for full 
      diagnosis of posttraumatic stress disorder (PTSD) at 6 months after MVA, 10 
      medication-naive patients with partial PTSD and 85 patients with no PTSD. PTSD 
      was evaluated by the Clinician-Administered PTSD Scale (CAPS). Serum BDNF levels 
      were measured shortly after the MVA (baseline) and at 6-month follow-up. RESULTS: 
      Posttrauma serum BDNF levels differed between the 3 groups after controlling for 
      age and sex (F = 3.41, p = 0.04), with unexpectedly higher serum BDNF levels seen 
      in the full-PTSD group compared with the no-PTSD group. Additional analysis of 
      patients with serum samples taken at baseline and at 6 months revealed the 
      full-PTSD group had significantly higher serum BDNF levels over the 6 months than 
      the no-PTSD group after controlling for age and sex (F = 6.44, p < 0.01). A 
      positive correlation was seen between changes in serum BDNF levels over 6 months 
      and the CAPS score at 6 months (r = 0.26, p = 0.014). CONCLUSIONS: The findings 
      of this study, the first to report longitudinal serum BDNF levels in MVA 
      survivors, suggest that elevated serum BDNF levels could be a biomarker of PTSD 
      after a traumatic event.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Matsuoka, Yutaka
AU  - Matsuoka Y
AD  - Department of Clinical Epidemiology, Translational Medical Center, National 
      Center of Neurology and Psychiatry, Tokyo, Japan. yutaka@ncnp.go.jp
FAU - Nishi, Daisuke
AU  - Nishi D
FAU - Noguchi, Hiroko
AU  - Noguchi H
FAU - Kim, Yoshiharu
AU  - Kim Y
FAU - Hashimoto, Kenji
AU  - Hashimoto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130615
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Accidents, Traffic/*psychology
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Stress Disorders, Post-Traumatic/*blood/diagnosis
MH  - Survivors/*psychology
EDAT- 2013/06/19 06:00
MHDA- 2014/10/01 06:00
CRDT- 2013/06/19 06:00
PHST- 2012/10/03 00:00 [received]
PHST- 2013/03/24 00:00 [accepted]
PHST- 2013/06/19 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - 000350950 [pii]
AID - 10.1159/000350950 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2013;68(1):44-50. doi: 10.1159/000350950. Epub 2013 Jun 15.