PMID- 23775023
OWN - NLM
STAT- MEDLINE
DCOM- 20140529
LR  - 20151119
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 21
IP  - 5
DP  - 2013 Oct
TI  - The impact of molecular morphology techniques on the expert diagnosis in 
      melanocytic skin neoplasms.
PG  - 483-92
LID - 10.1177/1066896913491323 [doi]
AB  - Thirteen melanocytic skin neoplasms with a consultation diagnosis by A. Bernard 
      Ackerman were submitted to immunohistochemistry for HMB-45, Ki67, cyclin D1, 
      e-cadherin, and p16; 9/13 cases underwent fluorescence in situ hybridization 
      (FISH) test targeting 6p25 (RREB1), 6q23 (MYB), centromere 6 (Cep6), and 11q13 
      (CCND1), as well as the centromere 7 (Cep7). A "consensus diagnosis" among 3 
      experts was also advocated both before and after morphomolecular information. 
      Three neoplasms with a consultation diagnosis of Spitz nevus showed at least 3 
      abnormal immunohistochemical patterns; 2 of these cases were also FISH-positive 
      for CCND1 gain, but none of them had a final consensus diagnosis of melanoma. Two 
      neoplasms with a consultation diagnosis of congenital nevus received a consensus 
      diagnosis of melanoma. Molecular morphology techniques can highlight the atypical 
      features of melanocytic neoplasms and support existence of a morphobiologic 
      "spectrum": This should be mirrored in the final report by abandoning the 
      dichotomic (benign vs malignant) diagnostic approach.
FAU - Ferrara, Gerardo
AU  - Ferrara G
AD  - 1Gaetano Rummo General Hospital, Benevento, Italy.
FAU - Misciali, Cosimo
AU  - Misciali C
FAU - Brenn, Thomas
AU  - Brenn T
FAU - Cerroni, Lorenzo
AU  - Cerroni L
FAU - Kazakov, Dmitry W
AU  - Kazakov DW
FAU - Perasole, Antonio
AU  - Perasole A
FAU - Russo, Rosa
AU  - Russo R
FAU - Ricci, Roberto
AU  - Ricci R
FAU - Crisman, Giuliana
AU  - Crisman G
FAU - Fanti, Pier Alessandro
AU  - Fanti PA
FAU - Passarini, Beatrice
AU  - Passarini B
FAU - Patrizi, Annalisa
AU  - Patrizi A
LA  - eng
PT  - Journal Article
DEP - 20130617
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/*analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanoma/*diagnosis/genetics/metabolism
MH  - Middle Aged
MH  - Nevus, Pigmented/diagnosis/genetics/metabolism
MH  - Skin Neoplasms/*diagnosis/genetics/metabolism
OTO - NOTNLM
OT  - atypical nevus
OT  - fluorescence in situ hybridization
OT  - immunohistochemistry
OT  - melanoma
EDAT- 2013/06/19 06:00
MHDA- 2014/05/30 06:00
CRDT- 2013/06/19 06:00
PHST- 2013/06/19 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/05/30 06:00 [medline]
AID - 1066896913491323 [pii]
AID - 10.1177/1066896913491323 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2013 Oct;21(5):483-92. doi: 10.1177/1066896913491323. Epub 
      2013 Jun 17.