PMID- 23775255
OWN - NLM
STAT- MEDLINE
DCOM- 20141126
LR  - 20211021
IS  - 1098-2302 (Electronic)
IS  - 0012-1630 (Print)
IS  - 0012-1630 (Linking)
VI  - 56
IP  - 4
DP  - 2014 May
TI  - Age differences in (+/-) 3,4-methylenedioxymethamphetamine (MDMA)-induced 
      conditioned taste aversions and monoaminergic levels.
PG  - 635-46
LID - 10.1002/dev.21132 [doi]
AB  - Preclinical work indicates that adolescent rats appear more sensitive to the 
      rewarding effects and less sensitive to the aversive effects of abused drugs. The 
      present investigation utilized the conditioned taste aversion (CTA) design to 
      measure the relative aversive effects of (+/-)3,4-methylenedioxymethamphetamine 
      (MDMA; 0, 1.0, 1.8, or 3.2 mg/kg) in adolescent and adult Sprague-Dawley rats. 
      After behavioral testing was complete, monoamine and associated metabolite levels 
      in discrete brain regions were quantified using high-performance liquid 
      chromatography coupled to electrochemical detection (HPLC-ECD) to determine if 
      adolescent animals displayed a different neurochemical profile than did adult 
      animals after being exposed to subcutaneous low doses of MDMA. Adolescent rats 
      displayed less robust MDMA-induced taste aversions than adults during acquisition 
      and on a final two-bottle aversion test. MDMA at these doses had no consistent 
      effect on monoamine levels in either age group, although levels did vary with 
      age. The relative insensitivity of adolescents to MDMA's aversive effects may 
      engender an increased vulnerability to MDMA abuse in this specific population.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Cobuzzi, Jennifer L
AU  - Cobuzzi JL
AD  - Psychopharmacology Laboratory, Department of Psychology, American University, 
      4400 Massachusetts Ave NW, Washington, DC, 20016.
FAU - Siletti, Kayla A
AU  - Siletti KA
FAU - Hurwitz, Zachary E
AU  - Hurwitz ZE
FAU - Wetzell, Bradley
AU  - Wetzell B
FAU - Baumann, Michael H
AU  - Baumann MH
FAU - Riley, Anthony L
AU  - Riley AL
LA  - eng
GR  - ZIA DA000523-06/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130615
PL  - United States
TA  - Dev Psychobiol
JT  - Developmental psychobiology
JID - 0164074
RN  - 0 (Biogenic Monoamines)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Biogenic Monoamines/*metabolism
MH  - Brain/*drug effects/metabolism
MH  - Conditioning, Psychological/*drug effects
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Taste/*drug effects
PMC - PMC4128552
MID - NIHMS609066
OTO - NOTNLM
OT  - CTA
OT  - HPLC
OT  - MDMA
OT  - adolescent
OT  - adult
OT  - monoamine
OT  - sprague-dawley rats
COIS- The authors have no conflicts of interest to declare.
EDAT- 2013/06/19 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/08/11
CRDT- 2013/06/19 06:00
PHST- 2013/01/02 00:00 [received]
PHST- 2013/04/12 00:00 [accepted]
PHST- 2013/06/19 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/08/11 00:00 [pmc-release]
AID - 10.1002/dev.21132 [doi]
PST - ppublish
SO  - Dev Psychobiol. 2014 May;56(4):635-46. doi: 10.1002/dev.21132. Epub 2013 Jun 15.