PMID- 23775864
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20161125
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Linking)
VI  - 70
IP  - 10
DP  - 2013 Oct
TI  - Environmental and occupational exposure to chemicals and telomere length in human 
      studies.
PG  - 743-9
LID - 10.1136/oemed-2012-101350 [doi]
AB  - Telomeres are complexes of tandem repeats of DNA (5'-TTAGGG-3') and protein that 
      cap eukaryotic chromosomes and play a critical role in chromosome stability. 
      Telomeres shorten with aging and this process can be accelerated by increased 
      oxidative stress and episodes of inflammation. Evidence is rapidly growing that 
      telomere length (TL) may be affected by environmental chemicals that have 
      frequently been associated with chronic diseases. In this article, we review the 
      published data on TL in relation to environmental and occupational exposure to 
      several chemicals based on our own and others' studies. The environmental and 
      occupational exposures associated with shorter TL include traffic-related air 
      pollution (ie, particulate matter (PM), black carbon (BC), and benzene and 
      toluene), polycyclic aromatic hydrocarbons (PAHs), N-nitrosamines, pesticides, 
      lead, exposure in car mechanical workshops, and hazardous waste exposure. 
      Arsenic, persistent organic pollutants (POPs) and short-term exposure to PM are 
      associated with longer TL. We discuss the possible reasons for the differences in 
      results, including time- and dose-related issues, study design, and possible 
      mechanisms involved in telomere regulation. We also discuss the future directions 
      and challenges for TL-related environmental and occupational health research, 
      such as investigation of TL in subpopulations of blood leukocytes, and the study 
      of genetic and epigenetic factors that may regulate telomere integrity using 
      longitudinal designs.
FAU - Zhang, Xiao
AU  - Zhang X
AD  - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern 
      University, Chicago, Illinois, USA.
FAU - Lin, Shao
AU  - Lin S
FAU - Funk, William E
AU  - Funk WE
FAU - Hou, Lifang
AU  - Hou L
LA  - eng
GR  - R21 ES020010/ES/NIEHS NIH HHS/United States
GR  - R21 ES020984-01/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20130617
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
RN  - 0 (Air Pollutants)
RN  - 0 (Hazardous Waste)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 2P299V784P (Lead)
SB  - IM
RPI - Postgrad Med J. 2013 Dec;89(1058):722-8. PMID: 24243983
MH  - Air Pollutants/*adverse effects
MH  - Environmental Exposure/*adverse effects
MH  - Hazardous Waste/adverse effects
MH  - Humans
MH  - Lead/adverse effects
MH  - Occupational Exposure/*adverse effects
MH  - Organic Chemicals/*adverse effects
MH  - Pesticides/adverse effects
MH  - Polycyclic Aromatic Hydrocarbons/adverse effects
MH  - Telomere/*drug effects
MH  - Telomere Shortening/*drug effects
OTO - NOTNLM
OT  - Materials, exposures and occupational groups
EDAT- 2013/06/19 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/06/19 06:00
PHST- 2013/06/19 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - oemed-2012-101350 [pii]
AID - 10.1136/oemed-2012-101350 [doi]
PST - ppublish
SO  - Occup Environ Med. 2013 Oct;70(10):743-9. doi: 10.1136/oemed-2012-101350. Epub 
      2013 Jun 17.