PMID- 23776377
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130619
LR  - 20211021
IS  - 1178-704X (Print)
IS  - 1178-704X (Electronic)
IS  - 1178-704X (Linking)
VI  - 5
DP  - 2012
TI  - Chronic lymphocytic leukemia-associated chromosomal abnormalities and miRNA 
      deregulation.
PG  - 21-8
LID - 10.2147/TACG.S18669 [doi]
AB  - Chronic lymphocytic leukemia is the most common leukemia in adults. By 
      cytogenetic investigations major subgroups of the disease can be identified that 
      reflect different routes of tumor development. Of these chromosomal deviations, 
      trisomy 12 and deletions of parts of either the long arm of chromosome 13, the 
      long arm of chromosome 11, or the short arm of chromosome 17 are most commonly 
      detected. In some of these aberrations the molecular target has been identified 
      as eg, ataxia telangiectasia mutated (ATM) in case of deletions of chromosomal 
      region 11q22~23 and the genes encoding microRNAs miR-15a/16-1 as likely targets 
      of deletions of chromosomal band 13q14.3. Of note, these aberrations do not 
      characterize independent subgroups but often coexist within the metaphases of one 
      tumor. Generally, complex aberrations are associated with a worse prognosis than 
      simple karyotypic alterations. Due to smaller sizes of the missing segment the 
      detection of recurrent deletions is not always possible by means of classical 
      cytogenetics but requires more advanced techniques as in particular fluorescence 
      in situ hybridization (FISH). Nevertheless, at this time it is not recommended to 
      replace classical cytogenetics by FISH because this would miss additional 
      information given by complex or secondary karyotypic alterations. However, the 
      results of cytogenetic analyses allow the stratification of prognostic and 
      predictive groups of the disease. Of these, the group characterized by deletions 
      involving TP53 is clinically most relevant. In the future refined methods as eg, 
      array-based comparative genomic hybridization will supplement the existing 
      techniques to characterize CLL.
FAU - Kiefer, Yvonne
AU  - Kiefer Y
AD  - Center for Human Genetics, University of Bremen, Bremen, Germany.
FAU - Schulte, Christoph
AU  - Schulte C
FAU - Tiemann, Markus
AU  - Tiemann M
FAU - Bullerdiek, Joern
AU  - Bullerdiek J
LA  - eng
PT  - Journal Article
DEP - 20120312
PL  - New Zealand
TA  - Appl Clin Genet
JT  - The application of clinical genetics
JID - 101579789
PMC - PMC3681189
OTO - NOTNLM
OT  - chromosomal abnormality
OT  - chronic lymphocytic leukemia
OT  - miRNA deregulation
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2012/03/12
CRDT- 2013/06/19 06:00
PHST- 2013/06/19 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2012/03/12 00:00 [pmc-release]
AID - tacg-5-021 [pii]
AID - 10.2147/TACG.S18669 [doi]
PST - epublish
SO  - Appl Clin Genet. 2012 Mar 12;5:21-8. doi: 10.2147/TACG.S18669. Print 2012.