PMID- 2377670
OWN - NLM
STAT- MEDLINE
DCOM- 19900905
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 36
IP  - 3
DP  - 1990 Jul
TI  - Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced 
      attenuation of exploratory activity in the rat.
PG  - 695-7
AB  - Six weeks after induction of bilateral sham or ibotenic acid lesions of the 
      medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic 
      beta-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel 
      open field. The attenuation of exploratory activity by FG-7142 was markedly 
      enhanced in the MPFC-lesioned rats. The results suggest that the behavioral 
      effects of MPFC lesions may be amplified under stressful conditions. Secondly, 
      the inhibition of exploratory activity by FG-7142 does not depend on its action 
      within the MPFC.
FAU - Jaskiw, G E
AU  - Jaskiw GE
AD  - Clinical Brain Disorders Branch, NIMH Research Center at St. Elizabeths, 
      Washington, DC 20032.
FAU - Weinberger, D R
AU  - Weinberger DR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Carbolines)
RN  - 0 (Oxazoles)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - 60PO70N1BP (FG 7142)
SB  - IM
MH  - Animals
MH  - Anxiety/chemically induced
MH  - Carbolines/*pharmacology
MH  - Cerebral Cortex/drug effects/*physiology
MH  - Exploratory Behavior/*drug effects
MH  - Ibotenic Acid/*toxicity
MH  - Male
MH  - Motor Activity/drug effects
MH  - Oxazoles/*toxicity
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stress, Physiological/physiopathology/*psychology
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
AID - 0091-3057(90)90276-N [pii]
AID - 10.1016/0091-3057(90)90276-n [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1990 Jul;36(3):695-7. doi: 10.1016/0091-3057(90)90276-n.