PMID- 23776720
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130619
LR  - 20211021
IS  - 2008-7802 (Print)
IS  - 2008-8213 (Electronic)
IS  - 2008-7802 (Linking)
VI  - 4
IP  - Suppl 2
DP  - 2013 May
TI  - The role of melatonin in the pathogenesis of multiple sclerosis: a case-control 
      study.
PG  - S180-4
AB  - BACKGROUND: The association between the prevalence of multiple sclerosis (MS) and 
      latitude gradient indicates the importance of environmental factors in MS 
      susceptibility. Sunlight's ultraviolet radiation, its ability to influence 
      melatonin, and an imbalance of melatonin in the central nervous system (CNS) may 
      be involved in this process. METHODS: This case-control study was conducted in 
      Isfahan MS Society (IMSS), Isfahan, Iran. Enrollment was limited to patients with 
      MS referring to the MS clinic of Alzahra and Kashani hospital during January and 
      February 2012. RESULTS: Thirty-five patients with MS and 35 healthy individuals 
      were included in our study. The melatonin levels were analyzed using 
      enzyme-linked immunosorbent assay (ELISA) kits. There was no significant 
      difference between saliva melatonin level of two groups (patients and healthy 
      individuals) (P = 0.417); however, after controlling the effect of age, a 
      significant difference (P = 0.022) was found. CONCLUSIONS: In the present study, 
      it is proposed that environmental conditions in Isfahan city might have increased 
      the susceptibility to MS, but more studies in different parts of the world are 
      needed to evaluate this claim.
FAU - Ghorbani, Abbas
AU  - Ghorbani A
AD  - Department of Neurology, Isfahan Neurosciences Research Center, School of 
      Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Salari, Mehri
AU  - Salari M
FAU - Shaygannejad, Vahid
AU  - Shaygannejad V
FAU - Norouzi, Rasul
AU  - Norouzi R
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Int J Prev Med
JT  - International journal of preventive medicine
JID - 101535380
PMC - PMC3678214
OTO - NOTNLM
OT  - Environmental factors
OT  - melatonin
OT  - multiple sclerosis
COIS- Conflict of Interest: None declared.
EDAT- 2013/06/19 06:00
MHDA- 2013/06/19 06:01
PMCR- 2013/05/01
CRDT- 2013/06/19 06:00
PHST- 2013/02/18 00:00 [received]
PHST- 2013/02/23 00:00 [accepted]
PHST- 2013/06/19 06:00 [entrez]
PHST- 2013/06/19 06:00 [pubmed]
PHST- 2013/06/19 06:01 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - IJPVM-4-180 [pii]
PST - ppublish
SO  - Int J Prev Med. 2013 May;4(Suppl 2):S180-4.