PMID- 23776782
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130619
LR  - 20211021
IS  - 2229-516X (Print)
IS  - 2248-9606 (Electronic)
IS  - 2229-516X (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jul
TI  - Clinico-epidemiological profile and high-level aminoglycoside resistance in 
      enterococcal septicemia from a tertiary care hospital in east Delhi.
PG  - 80-3
LID - 10.4103/2229-516X.91149 [doi]
AB  - BACKGROUND: Emergence of high-level aminoglycoside and glycopeptide resistance 
      has significantly contributed to the mortality, particularly in serious 
      enterococcal infections. OBJECTIVES: This study was aimed to determine the 
      prevalence of high-level gentamicin resistance (HLGR), high-level streptomycin 
      resistance (HLSR) and vancomycin resistance in enterococcal isolates recovered 
      from patients with bacteremia. MATERIALS AND METHODS: A total of 110 blood 
      culture isolates of enterococci were recovered from septicemic patients. Routine 
      antibiotic susceptibility testing was performed and screening for ampilcillin, 
      high-level aminoglycoside resistance (HLAR) and high-level vancomycin resistance 
      was done by agar screen method. RESULTS: Out of 110 isolates, Enterococcus 
      faecium accounted for 53% of these isolates, followed by Enterococcus fecalis 
      (33%), Enterococcus casseliflavus (8%), Enterococcus raffinosus (4%) and 
      Enterococcus dispar (2%). Resistance to ampicillin, HLGR, HLSR and HLAR was 
      detected in 58%, 62%, 58% and 54% of the isolates, respectively. No isolate was 
      resistant to vancomycin. CONCLUSION: This study illustrates the high prevalence 
      of HLAR in enterococci from patients with septicemia in our region, which 
      emphasizes the need to predict synergy between beta-lactams and aminoglycosides 
      for management of enterococcal infections.
FAU - Jain, Sarika
AU  - Jain S
AD  - Department of Microbiology, University College of Medical Sciences & Guru Teg 
      Bahadur Hospital, Delhi, India.
FAU - Kumar, Ashwani
AU  - Kumar A
FAU - Kashyap, Bineeta
AU  - Kashyap B
FAU - Kaur, Iqbal R
AU  - Kaur IR
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Appl Basic Med Res
JT  - International journal of applied & basic medical research
JID - 101579831
PMC - PMC3657974
OTO - NOTNLM
OT  - Antibiotic resistance
OT  - enterococcus
OT  - vancomycin
COIS- Conflict of Interest: None declared.
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
PMCR- 2011/07/01
CRDT- 2013/06/19 06:00
PHST- 2013/06/19 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - IJABMR-1-80 [pii]
AID - 10.4103/2229-516X.91149 [doi]
PST - ppublish
SO  - Int J Appl Basic Med Res. 2011 Jul;1(2):80-3. doi: 10.4103/2229-516X.91149.