PMID- 23776807
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 2229-516X (Print)
IS  - 2248-9606 (Electronic)
IS  - 2229-516X (Linking)
VI  - 2
IP  - 1
DP  - 2012 Jan
TI  - Effect of aqueous leaves extract of Ocimum gratissimum on hematological 
      parameters in rats.
PG  - 38-42
LID - 10.4103/2229-516X.96807 [doi]
AB  - OBJECTIVE: This study aims to elucidate the effect of Ocimum gratissimum on 
      hematological parameters in rats. MATERIALS AND METHODS: Thirty male albino 
      Wistar rats were randomly assigned into three groups of ten rats each. Group 1 
      was control, while groups 2 (LD) and 3 (HD) received 500 mg/kg and 1000 mg/kg 
      body weight, respectively, of the extract orally once daily. Rats in all three 
      groups received normal rat chow and drinking water ad libitum for 28 days. 
      Complete blood count was done using an automatic counter. RESULTS: The HD group 
      had significantly (P<.05) higher red blood cell (RBC) counts, packed cell volume 
      (PCV), hemoglobin (Hb), and platelet counts as compared with the control and LD 
      groups. No significant changes were observed in the total white blood cell (WBC) 
      count of the three groups, but significantly (P<.05) lower lymphocyte and higher 
      neutrophil counts were observed in the HD group compared with the LD group. The 
      mean platelet volume (MPV), platelet-large cell ratio (P-LCR), and platelet 
      distribution width (PDW) were significantly (P<.05) reduced in the HD compared 
      with the LD group. The mean corpuscular volume (MCV) and RBC distribution 
      width-standard deviation were significantly (P<.05) lower in the HD group than in 
      control. No significant changes were observed in levels of mean corpuscular 
      hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and RBC 
      distribution width-coefficient of variation among the groups. CONCLUSION: We 
      conclude that oral administration of O gratissimum increases RBC, PCV, Hb, 
      platelet count, and neutrophils and also leads to a decrease in platelet indices 
      (i.e., MPV, P-LCR, and PDW).
FAU - Ofem, Oe
AU  - Ofem O
AD  - Department of Physiology, College of Medical Sciences, University of Calabar, 
      Calabar, Nigeria.
FAU - Ani, Ej
AU  - Ani E
FAU - Eno, Ae
AU  - Eno A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Appl Basic Med Res
JT  - International journal of applied & basic medical research
JID - 101579831
PMC - PMC3657984
OTO - NOTNLM
OT  - Blood indices
OT  - Hb
OT  - O gratissimum
OT  - differential white blood cell
OT  - packed cell volume
OT  - platelet
OT  - red blood cell
OT  - total WBC
COIS- Conflict of Interest: None declared.
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2012/01/01
CRDT- 2013/06/19 06:00
PHST- 2013/06/19 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - IJABMR-2-38 [pii]
AID - 10.4103/2229-516X.96807 [doi]
PST - ppublish
SO  - Int J Appl Basic Med Res. 2012 Jan;2(1):38-42. doi: 10.4103/2229-516X.96807.