PMID- 23777448
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 61
IP  - 26
DP  - 2013 Jul 3
TI  - Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways 
      through AMPK activation in triple-negative breast cancer cells.
PG  - 6366-75
LID - 10.1021/jf4012455 [doi]
AB  - Demethoxycurcumin (DMC), curcumin (Cur), and bisdemethoxycurcumin (BDMC) are 
      major forms of curcuminoids found in the rhizomes of turmeric. This study 
      examined the effects of three curcuminoid analogues on breast cancer cells. The 
      results revealed that DMC demonstrated the most potent cytotoxic effects on 
      breast cancer MDA-MB-231 cells. Compared with estrogen receptor (ER)-positive or 
      HER2-overexpressing breast cancer cells, DMC demonstrated the most efficient 
      cytotoxic effects on triple-negative breast cancer (TNBC) cells. However, 
      nonmalignant MCF-10A cells were unaffected by DMC treatment. The study showed 
      that DMC activated AMPK in TNBC cells. Once activated, AMPK inhibited eukaryotic 
      initiation factor 4E-binding protein-1 (4E-BP1) signaling and mRNA translation 
      via mammalian target of rapamycin (mTOR) and decreased the activity and/or 
      expression of lipogenic enzymes, such as fatty acid synthase (FASN) and 
      acetyl-CoA carboxylase (ACC). DMC also targeted multiple AMPK downstream 
      pathways. Among these, the dephosphorylation of Akt is noteworthy because it 
      circumvents the feedback activation of Akt that results from mTOR inhibition. 
      Moreover, DMC suppressed LPS-induced IL-6 production, thereby blocking subsequent 
      Stat3 activation. In addition, DMC also sustained epidermal growth factor 
      receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2. These 
      results suggest that DMC is a potent AMPK activator that acts through a broad 
      spectrum of anti-TNBC activities.
FAU - Shieh, Jiunn-Min
AU  - Shieh JM
AD  - Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Chen, Yung-Chan
AU  - Chen YC
FAU - Lin, Ying-Chao
AU  - Lin YC
FAU - Lin, Jia-Ni
AU  - Lin JN
FAU - Chen, Wei-Chih
AU  - Chen WC
FAU - Chen, Yang-Yuan
AU  - Chen YY
FAU - Ho, Chi-Tang
AU  - Ho CT
FAU - Way, Tzong-Der
AU  - Way TD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130618
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Diarylheptanoids)
RN  - 0 (Enzyme Activators)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - IT942ZTH98 (Curcumin)
RN  - W2F8059T80 (demethoxycurcumin)
SB  - IM
MH  - AMP-Activated Protein Kinases/chemistry/metabolism
MH  - Anticarcinogenic Agents/*pharmacology
MH  - Carcinogenesis/*drug effects
MH  - Cell Line, Tumor
MH  - Curcumin/*analogs & derivatives/pharmacology
MH  - Diarylheptanoids
MH  - Energy Metabolism/*drug effects
MH  - Enzyme Activators/pharmacology
MH  - Female
MH  - Humans
MH  - Signal Transduction/*drug effects
MH  - Triple Negative Breast Neoplasms/*drug therapy/metabolism/prevention & control
EDAT- 2013/06/20 06:00
MHDA- 2014/01/01 06:00
CRDT- 2013/06/20 06:00
PHST- 2013/06/20 06:00 [entrez]
PHST- 2013/06/20 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - 10.1021/jf4012455 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2013 Jul 3;61(26):6366-75. doi: 10.1021/jf4012455. Epub 2013 
      Jun 18.