PMID- 23777493
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20151119
IS  - 1365-2230 (Electronic)
IS  - 0307-6938 (Linking)
VI  - 38
IP  - 5
DP  - 2013 Jul
TI  - Pityriasis rubra pilaris-like reaction induced by imatinib.
PG  - 520-2
LID - 10.1111/ced.12081 [doi]
AB  - Imatinib, a kinase inhibitor, is currently approved for the treatment of chronic 
      myeloid leukaemia, gastrointestinal stromal tumours (GIST), and other malignant 
      conditions such as dermatofibrosarcoma protuberans. Treatment with imatinib is 
      generally well tolerated, but some cutaneous adverse events (AEs), such as 
      exanthematous papular eruptions and Stevens-Johnson syndrome have been reported. 
      We report a case of a pityriasis rubra pilaris (PRP)-like eruption associated 
      with this drug. Although cutaneous AEs associated with imatinib are relatively 
      common (up to 69% of cases), no previous cases of PRP-like eruptions related to 
      this drug have been described previously, to our knowledge.
CI  - (c) 2013 British Association of Dermatologists.
FAU - Plana, A
AU  - Plana A
AD  - Department of Dermatology, Hospital Universitari Germans Trias I Pujol, 
      Universitat Autonoma de Barcelona, Badalona, Spain. adriplanapla@yahoo.es
FAU - Carrascosa, J M
AU  - Carrascosa JM
FAU - Vilavella, M
AU  - Vilavella M
FAU - Ferrandiz, C
AU  - Ferrandiz C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Clin Exp Dermatol
JT  - Clinical and experimental dermatology
JID - 7606847
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Benzamides)
RN  - 0 (Piperazines)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Pyrimidines)
RN  - 8A1O1M485B (Imatinib Mesylate)
SB  - IM
MH  - Antineoplastic Agents/*adverse effects
MH  - Benzamides/*adverse effects
MH  - Drug Eruptions/*etiology
MH  - Humans
MH  - Imatinib Mesylate
MH  - Male
MH  - Middle Aged
MH  - Piperazines/*adverse effects
MH  - Pityriasis Rubra Pilaris/*chemically induced
MH  - Protein Kinase Inhibitors/*adverse effects
MH  - Pyrimidines/*adverse effects
EDAT- 2013/06/20 06:00
MHDA- 2013/10/22 06:00
CRDT- 2013/06/20 06:00
PHST- 2012/09/23 00:00 [accepted]
PHST- 2013/06/20 06:00 [entrez]
PHST- 2013/06/20 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - 10.1111/ced.12081 [doi]
PST - ppublish
SO  - Clin Exp Dermatol. 2013 Jul;38(5):520-2. doi: 10.1111/ced.12081.