PMID- 23777506
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 12
DP  - 2013 Jun 19
TI  - Miglitol improves postprandial endothelial dysfunction in patients with acute 
      coronary syndrome and new-onset postprandial hyperglycemia.
PG  - 92
LID - 10.1186/1475-2840-12-92 [doi]
AB  - BACKGROUND: Hyperglycemia, a risk factor for development of cardiovascular 
      disease, causes endothelial dysfunction. Alpha-glucosidase inhibitors (alpha-GIs) 
      improve postprandial hyperglycemia (PPHG) and may have favorable effects on 
      associated cardiovascular disease. Effects of alpha-GIs in patients with acute 
      coronary syndrome (ACS) and PPHG remain unclear; thus, we assessed the effect of 
      alpha-GI miglitol on endothelial function in such patients by digital reactive 
      hyperemia peripheral arterial tonometry (RH-PAT). METHODS: Fifty-four patients 
      with ACS who underwent primary percutaneous coronary intervention were enrolled 
      in the study: 36 with new-onset PPHG and 18 with normal glucose tolerance. 
      Eighteen PPHG patients were given 50 mg of miglitol with each meal for 1 week. 
      Endothelial function was assessed on the basis of the RH-PAT index (RHI) before 
      and after the 1-week miglitol treatment. The other 18 PPHG patients and the 18 
      NGT patients were not given any anti-diabetic agent for 1 week, and endothelial 
      function was assessed. RESULTS: Postprandial RHI decreased significantly in 
      patients with PPHG. Miglitol improved PPHG significantly; postprandial RHI also 
      improved (p = 0.007). Significant inverse correlation was found between the 
      postprandial change in RHI and postprandial fasting-to-60-minutes surge in 
      glucose (r = -0.382, p = 0.009). Moreover, the improvement in endothelial 
      function correlated with the reduced postprandial glucose surge achieved with 
      miglitol (r = -0.462, p = 0.001). CONCLUSIONS: Postprandial changes in glucose 
      are related to endothelial dysfunction in ACS. Miglitol-based improvement in PPHG 
      appears to improve endothelial function. The effect of miglitol on 
      glucose-dependent endothelial function might improve outcomes of ACS.
FAU - Kitano, Daisuke
AU  - Kitano D
AD  - Division of Cardiology, Department of Medicine, Nihon University School of 
      Medicine, 30-1 Ohyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
FAU - Chiku, Masaaki
AU  - Chiku M
FAU - Li, Yuxin
AU  - Li Y
FAU - Okumura, Yasuo
AU  - Okumura Y
FAU - Fukamachi, Daisuke
AU  - Fukamachi D
FAU - Takayama, Tadateru
AU  - Takayama T
FAU - Hiro, Takafumi
AU  - Hiro T
FAU - Saito, Satoshi
AU  - Saito S
FAU - Hirayama, Atsushi
AU  - Hirayama A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130619
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Hypoglycemic Agents)
RN  - 0V5436JAQW (miglitol)
RN  - 19130-96-2 (1-Deoxynojirimycin)
SB  - IM
MH  - 1-Deoxynojirimycin/*analogs & derivatives/therapeutic use
MH  - Acute Coronary Syndrome/complications/*therapy
MH  - Aged
MH  - Case-Control Studies
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Hyperglycemia/complications/*drug therapy
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - Postprandial Period
MH  - Treatment Outcome
PMC - PMC3691582
EDAT- 2013/06/20 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/06/19
CRDT- 2013/06/20 06:00
PHST- 2013/02/05 00:00 [received]
PHST- 2013/06/17 00:00 [accepted]
PHST- 2013/06/20 06:00 [entrez]
PHST- 2013/06/20 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/06/19 00:00 [pmc-release]
AID - 1475-2840-12-92 [pii]
AID - 10.1186/1475-2840-12-92 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2013 Jun 19;12:92. doi: 10.1186/1475-2840-12-92.