PMID- 23777550
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20151119
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Linking)
VI  - 23
IP  - 10
DP  - 2013 Oct
TI  - Differences in heart rate profile during exercise among subjects with subclinical 
      thyroid disease.
PG  - 1226-32
LID - 10.1089/thy.2013.0043 [doi]
AB  - BACKGROUND: Clinical thyroid disease is associated with changes in the 
      cardiovascular system, including changes in heart rate during exercise. However, 
      data on the relation between subclinical thyroid disease (SCTD) and heart rate 
      during exercise are limited. METHODS: We investigated 3799 apparently healthy 
      subjects who were evaluated in the Institute for Preventive Medicine at the Sheba 
      Medical Center. All subjects answered standard health questionnaires; were 
      examined by a physician; completed routine blood tests including thyrotropin, 
      free triiodothyronine, and free thyroxine levels; and underwent a treadmill 
      exercise according to the Bruce protocol. Subjects with known thyroid disease or 
      those who were taking thyroid-related drugs were excluded from the analysis. 
      Heart rate profile was compared between patients with subclinical hypothyroidism 
      (SCHypoT), patients with normal thyroid function, and patients with subclinical 
      hyperthyroidism (SCHyperT) using propensity score matching. RESULTS: Seventy 
      patients had SCHyperT and 273 had SCHypoT. Compared with age- and sex-matched 
      normal subjects, SCHyperT subjects had a higher resting heart rate (83+/-17 vs. 
      76+/-12 beats per minute [bpm], p=0.006), a significantly higher recovery heart 
      rate (94+/-12 vs. 90+/-12 bpm, p=0.045), and a significantly lower heart rate reserve 
      (80+/-20 vs. 87+/-18 bpm, p=0.006). Subjects with SCHypoT showed a trend toward a 
      lower resting heart rate (75+/-13 vs. 77+/-15 bpm, p=0.09) and had a significantly 
      lower recovery heart rate (88+/-12 vs. 90+/-13 bpm, p=0.035). There was no 
      significant difference in exercise duration or blood pressure between subjects 
      with SCTD and their matched normal controls. CONCLUSIONS: Subjects with SCTD have 
      a significantly different heart rate profile during rest, exercise, and recovery.
FAU - Maor, Elad
AU  - Maor E
AD  - 1 Leviev Heart Institute, Chaim Sheba Medical Center , Tel Hashomer, Israel .
FAU - Kivity, Shaye
AU  - Kivity S
FAU - Kopel, Eran
AU  - Kopel E
FAU - Segev, Shlomo
AU  - Segev S
FAU - Sidi, Yechezkel
AU  - Sidi Y
FAU - Goldenberg, Ilan
AU  - Goldenberg I
FAU - Olchovsky, David
AU  - Olchovsky D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130914
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Thyroid Hormones)
SB  - IM
MH  - Adult
MH  - Blood Pressure
MH  - Cardiovascular System/*physiopathology
MH  - Cohort Studies
MH  - Electronic Health Records
MH  - *Exercise
MH  - Exercise Test
MH  - *Exercise Tolerance
MH  - Female
MH  - *Heart Rate
MH  - Humans
MH  - Hyperthyroidism/blood/*physiopathology
MH  - Hypothyroidism/blood/*physiopathology
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Thyroid Hormones/blood
EDAT- 2013/06/20 06:00
MHDA- 2014/05/03 06:00
CRDT- 2013/06/20 06:00
PHST- 2013/06/20 06:00 [entrez]
PHST- 2013/06/20 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - 10.1089/thy.2013.0043 [doi]
PST - ppublish
SO  - Thyroid. 2013 Oct;23(10):1226-32. doi: 10.1089/thy.2013.0043. Epub 2013 Sep 14.