PMID- 23777795
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20151119
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 252
DP  - 2013 Sep 1
TI  - Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: 
      comparison with memantine.
PG  - 415-21
LID - S0166-4328(13)00361-6 [pii]
LID - 10.1016/j.bbr.2013.06.016 [doi]
AB  - Alzheimer's disease (AD) as a neurodegenerative brain disorder is the most common 
      cause of dementia. To date, there is no causative treatment for AD and there are 
      few preventive treatments either. The sphingosine-1-phosphate receptor modulator 
      FTY720 (fingolimod) prevents lymphocytes from contributing to an autoimmune 
      reaction and has been approved for multiple sclerosis treatment. In concert with 
      other studies showing the anti-inflammatory and protective effect of FTY720 in 
      some neurodegenerative disorders like ischemia, we have recently shown that 
      FTY720 chronic administration prevents from impairment of spatial learning and 
      memory in AD rats. Here FTY720 was examined on AD rats in comparison to the only 
      clinically approved NMDA receptor antagonist, Memantine. Passive avoidance task 
      showed significant memory restoration in AD animals received FTY720 comparable to 
      Memantine. Upon gene profiling by QuantiGene Plex, this behavioral outcomes was 
      concurrent with considerable alterations in some genes transcripts like that of 
      mitogen activated protein kinases (MAPKs) and some inflammatory markers that may 
      particularly account for the detected decline in hippocampal neural damage or 
      memory impairment associated with AD. From a therapeutic standpoint, our findings 
      conclude that FTY720 may suggest new opportunities for AD management probably 
      based on several modulatory effects on genes involved in cell death or survival.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Hemmati, Fatemeh
AU  - Hemmati F
AD  - Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 
      Kuala Lumpur, Malaysia.
FAU - Dargahi, Leila
AU  - Dargahi L
FAU - Nasoohi, Sanaz
AU  - Nasoohi S
FAU - Omidbakhsh, Rana
AU  - Omidbakhsh R
FAU - Mohamed, Zahurin
AU  - Mohamed Z
FAU - Chik, Zamri
AU  - Chik Z
FAU - Naidu, Murali
AU  - Naidu M
FAU - Ahmadiani, Abolhassan
AU  - Ahmadiani A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130615
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Cytokines)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (Propylene Glycols)
RN  - 0 (amyloid beta-protein (1-42))
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - G926EC510T (Fingolimod Hydrochloride)
RN  - NGZ37HRE42 (Sphingosine)
RN  - W8O17SJF3T (Memantine)
SB  - IM
MH  - Alzheimer Disease/chemically induced/pathology/*prevention & control
MH  - Amyloid beta-Peptides/toxicity
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Cytokines/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Female
MH  - Fingolimod Hydrochloride
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/pathology
MH  - Male
MH  - Memantine/*therapeutic use
MH  - Mitogen-Activated Protein Kinases/genetics/*metabolism
MH  - Nerve Degeneration/chemically induced/prevention & control
MH  - Neuroprotective Agents/*therapeutic use
MH  - Peptide Fragments/toxicity
MH  - Propylene Glycols/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sex Factors
MH  - Sphingosine/*analogs & derivatives/therapeutic use
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - FTY720
OT  - Gene profiling
OT  - Memantine
OT  - Sphingosine-1-phosphate
EDAT- 2013/06/20 06:00
MHDA- 2013/10/29 06:00
CRDT- 2013/06/20 06:00
PHST- 2013/04/24 00:00 [received]
PHST- 2013/06/03 00:00 [revised]
PHST- 2013/06/07 00:00 [accepted]
PHST- 2013/06/20 06:00 [entrez]
PHST- 2013/06/20 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - S0166-4328(13)00361-6 [pii]
AID - 10.1016/j.bbr.2013.06.016 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Sep 1;252:415-21. doi: 10.1016/j.bbr.2013.06.016. Epub 2013 
      Jun 15.