PMID- 23778975
OWN - NLM
STAT- MEDLINE
DCOM- 20141231
LR  - 20211021
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 40
IP  - 3
DP  - 2014 May
TI  - Prefrontal brain network connectivity indicates degree of both schizophrenia risk 
      and cognitive dysfunction.
PG  - 653-64
LID - 10.1093/schbul/sbt077 [doi]
AB  - OBJECTIVE: Cognitive dysfunction is a core feature of schizophrenia, and persons 
      at risk for schizophrenia may show subtle deficits in attention and working 
      memory. In this study, we investigated the relationship between integrity of 
      functional brain networks and performance in attention and working memory tasks 
      as well as schizophrenia risk. METHODS: A total of 235 adults representing 3 
      levels of risk (102 outpatients with schizophrenia, 70 unaffected first-degree 
      relatives of persons with schizophrenia, and 63 unrelated healthy controls [HCs]) 
      completed resting-state functional magnetic resonance imaging and a battery of 
      attention and working memory tasks (Brief Test of Attention, Hopkins Verbal 
      Learning Test, and Brief Visuospatial Memory Test) on the same day. Functional 
      networks were defined based on coupling with seeds in the dorsal anterior 
      cingulate cortex, dorsolateral prefrontal cortex (DLPFC), medial prefrontal 
      cortex (MPFC), and primary visual cortex. Networks were then dissected into 
      regional clusters of connectivity that were used to generate individual 
      interaction matrices representing functional connectivity within each network. 
      RESULTS: Both patients with schizophrenia and their first-degree relatives showed 
      cognitive dysfunction compared with HCs. First canonicals indicated an inverse 
      relationship between cognitive performance and connectivity within the DLPFC and 
      MPFC networks. Multivariate analysis of variance revealed multivariate main 
      effects of higher schizophrenia risk status on increased connectivity within the 
      DLPFC and MPFC networks. CONCLUSIONS: These data suggest that excessive 
      connectivity within brain networks coupled to the DLPFC and MPFC, respectively, 
      accompany cognitive deficits in persons at risk for schizophrenia. This might 
      reflect compensatory reactions in neural systems required for cognitive 
      processing of attention and working memory tasks to brain changes associated with 
      schizophrenia.
FAU - Unschuld, Paul G
AU  - Unschuld PG
AD  - *To whom correspondence should be addressed; Division of Psychiatry Research and 
      Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, CH-8032 
      Zurich, Switzerland; tel: +41-44-3891-453, fax: +41-44-3891-447, e-mail: 
      paul.unschuld@uzh.ch.
FAU - Buchholz, Alison S
AU  - Buchholz AS
FAU - Varvaris, Mark
AU  - Varvaris M
FAU - van Zijl, Peter C M
AU  - van Zijl PC
FAU - Ross, Christopher A
AU  - Ross CA
FAU - Pekar, James J
AU  - Pekar JJ
FAU - Hock, Christoph
AU  - Hock C
FAU - Sweeney, John A
AU  - Sweeney JA
FAU - Tamminga, Carol A
AU  - Tamminga CA
FAU - Keshavan, Matcheri S
AU  - Keshavan MS
FAU - Pearlson, Godfrey D
AU  - Pearlson GD
FAU - Thaker, Gunvant K
AU  - Thaker GK
FAU - Schretlen, David J
AU  - Schretlen DJ
LA  - eng
GR  - R01 MH096913/MH/NIMH NIH HHS/United States
GR  - P41-EB015909/EB/NIBIB NIH HHS/United States
GR  - R01 MH077852/MH/NIMH NIH HHS/United States
GR  - T32MH015330/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130618
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Attention/physiology
MH  - Case-Control Studies
MH  - Cognition Disorders/genetics/*physiopathology/psychology
MH  - *Family
MH  - Female
MH  - Functional Neuroimaging
MH  - Gyrus Cinguli/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neural Pathways/*physiopathology
MH  - Prefrontal Cortex/*physiopathology
MH  - Risk
MH  - Schizophrenia/genetics/*physiopathology
MH  - *Schizophrenic Psychology
MH  - Visual Cortex/*physiopathology
PMC - PMC3984516
OTO - NOTNLM
OT  - attention
OT  - default-mode network
OT  - fMRI
OT  - resting state
OT  - working memory
EDAT- 2013/06/20 06:00
MHDA- 2015/01/01 06:00
PMCR- 2015/05/01
CRDT- 2013/06/20 06:00
PHST- 2013/06/20 06:00 [entrez]
PHST- 2013/06/20 06:00 [pubmed]
PHST- 2015/01/01 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - sbt077 [pii]
AID - 10.1093/schbul/sbt077 [doi]
PST - ppublish
SO  - Schizophr Bull. 2014 May;40(3):653-64. doi: 10.1093/schbul/sbt077. Epub 2013 Jun 
      18.