PMID- 23780687
OWN - NLM
STAT- MEDLINE
DCOM- 20141117
LR  - 20211025
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 36
IP  - 4
DP  - 2014 Apr
TI  - Predictors of cervical lymph node metastasis in salivary gland cancer.
PG  - 517-23
LID - 10.1002/hed.23332 [doi]
AB  - BACKGROUND: This study compares clinicopathological parameters with novel 
      molecular markers for predicting cervical lymph node metastasis in salivary gland 
      cancer. METHODS: Three hundred sixteen salivary gland carcinomas were included in 
      this study. Genomic epidermal growth factor receptor (EGFR), human epidermal 
      growth factor receptor 2 (HER2), phosphatase and tensin homolog (PTEN), and 
      hepatocyte growth factor receptor (MET) was determined by fluorescence in situ 
      hybridization (FISH). Chi-square tests, multivariate regression, and Kaplan-Meier 
      survival analysis were used for statistics. RESULTS: Nodal staging determines 
      long-term survival. Clinicopathological parameters associated with positive neck 
      nodes are advanced age (p = .006), T3/T4 classification, histological high-grade 
      malignancy, and diagnosis of salivary duct carcinoma (p < .001 each). Neck node 
      metastases also correlate with copy number gain of EGFR (p = .004) and HER2, 
      aberration of MET, and deletion of PTEN (p < .001 each). Multivariate analysis 
      showed SDC (p = .002) to be the strongest predictor of lymph node metastasis, 
      followed by MET aberration (p = .009), T3/T4 classification (p = .017), PTEN 
      deletion (p = .042), and adenocarcinoma not otherwise specified (NOS; p = .047). 
      CONCLUSION: The histological subtype is crucial for decisions regarding neck 
      dissection. New molecular parameters may also indicate elective treatment of the 
      neck.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Ettl, Tobias
AU  - Ettl T
AD  - Department of Oral and Maxillofacial Surgery, Regensburg University Medical 
      Center, Regensburg, Germany.
FAU - Gosau, Martin
AU  - Gosau M
FAU - Brockhoff, Gero
AU  - Brockhoff G
FAU - Schwarz-Furlan, Stephan
AU  - Schwarz-Furlan S
FAU - Agaimy, Abbas
AU  - Agaimy A
FAU - Reichert, Torsten E
AU  - Reichert TE
FAU - Rohrmeier, Christian
AU  - Rohrmeier C
FAU - Zenk, Johannes
AU  - Zenk J
FAU - Iro, Heinrich
AU  - Iro H
LA  - eng
PT  - Journal Article
DEP - 20130618
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Age Factors
MH  - Carcinoma/genetics/metabolism/mortality/*pathology
MH  - ErbB Receptors/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neck Dissection
MH  - Neoplasm Staging
MH  - PTEN Phosphohydrolase/genetics/metabolism
MH  - Proto-Oncogene Proteins c-met/genetics/metabolism
MH  - Receptor, ErbB-2/metabolism
MH  - Retrospective Studies
MH  - Salivary Gland Neoplasms/genetics/metabolism/mortality/*pathology
OTO - NOTNLM
OT  - MET
OT  - PTEN
OT  - nodal metastasis
OT  - predictors
OT  - salivary gland cancer
EDAT- 2013/06/20 06:00
MHDA- 2014/11/18 06:00
CRDT- 2013/06/20 06:00
PHST- 2013/02/08 00:00 [accepted]
PHST- 2013/06/20 06:00 [entrez]
PHST- 2013/06/20 06:00 [pubmed]
PHST- 2014/11/18 06:00 [medline]
AID - 10.1002/hed.23332 [doi]
PST - ppublish
SO  - Head Neck. 2014 Apr;36(4):517-23. doi: 10.1002/hed.23332. Epub 2013 Jun 18.