PMID- 23781882
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20211021
IS  - 2000-1967 (Electronic)
IS  - 0300-9734 (Print)
IS  - 0300-9734 (Linking)
VI  - 118
IP  - 4
DP  - 2013 Nov
TI  - Effect of dexmedetomidine on plasma brain-derived neurotrophic factor: A 
      double-blind, randomized and placebo-controlled study.
PG  - 235-9
LID - 10.3109/03009734.2013.808295 [doi]
AB  - BACKGROUND: Dexmedetomidine (DEX) has neuro-protective effects, but the clinical 
      mechanism remains unclear. METHOD: Forty patients were randomly divided into two 
      groups: group A (control) and group B (treated with DEX). Plasma concentrations 
      of brain-derived neurotrophic factor (BDNF) were determined in blood samples 
      using enzyme-linked immunosorbent assays at five time points: T1 (baseline), T2 
      (15 minutes after intubation and before the surgery was started), T3 (the end of 
      surgery), T4 (10 minutes after extubation in the post-anesthesia care unit), and 
      T5 (24 hours after the surgery). Changes in bispect (BIS) index, heart rates, and 
      doses of anesthetics used for induction were also recorded. RESULTS: Baseline 
      plasma concentrations of BDNF did not differ between group A and group B; 15 
      minutes after induction, concentrations of plasma BDNF were significantly reduced 
      in group A. Twenty-four hours after surgery, the concentration was still higher 
      in group B than in group A. In contrast, plasma concentrations of BDNF at other 
      time points tested did not differ between the two groups. CONCLUSION: It appears 
      that DEX could reverse the reduced plasma concentrations of BDNF caused by 
      anesthetics, and this effect lasted for 24 hours after surgery.
FAU - Yang, Lin
AU  - Yang L
AD  - Department of Anesthesiology, The Second Xiangya Hospital, Central South 
      University and Anesthesiology Research Institute, Central South University , 
      Changsha, Hunan , People's Republic of China.
FAU - Xu, Jun-Mei
AU  - Xu JM
FAU - Jiang, Xinghua
AU  - Jiang X
FAU - Ruan, Wei
AU  - Ruan W
FAU - Cui, Yulong
AU  - Cui Y
FAU - He, Liang
AU  - He L
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130620
PL  - Sweden
TA  - Ups J Med Sci
JT  - Upsala journal of medical sciences
JID - 0332203
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hypnotics and Sedatives)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Anesthesia, General/methods
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Dexmedetomidine/*therapeutic use
MH  - Diskectomy
MH  - Double-Blind Method
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Hypnotics and Sedatives/*therapeutic use
MH  - Intervertebral Disc Degeneration/surgery
MH  - Lumbar Vertebrae/surgery
MH  - Male
MH  - Middle Aged
MH  - Time Factors
PMC - PMC4190894
EDAT- 2013/06/21 06:00
MHDA- 2014/05/13 06:00
PMCR- 2013/11/01
CRDT- 2013/06/21 06:00
PHST- 2013/06/21 06:00 [entrez]
PHST- 2013/06/21 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - UPS_A_808295_O [pii]
AID - 10.3109/03009734.2013.808295 [doi]
PST - ppublish
SO  - Ups J Med Sci. 2013 Nov;118(4):235-9. doi: 10.3109/03009734.2013.808295. Epub 
      2013 Jun 20.