PMID- 23782302
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20221207
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 42
IP  - 6
DP  - 2013
TI  - The CTLA-4 and MCP-1 polymorphisms and susceptibility to systemic sclerosis: a 
      meta-analysis.
PG  - 481-92
LID - 10.3109/08820139.2013.789910 [doi]
AB  - OBJECTIVE: The aim of this study was to explore whether cytotoxic T lymphocyte 
      antigen-4 (CTLA-4) and monocyte chemoattractant protein-1 (MCP-1) polymorphisms 
      confer susceptibility to systemic sclerosis (SSc). METHODS: MEDLINE and manual 
      search were utilized to identify available articles. A meta-analysis was 
      conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, -1661 A/G, 
      and -1722 C/T, and MCP-1 -2518 A/G polymorphisms, using a fixed-effect or 
      random-effect model based on between-study heterogeneity. RESULTS: Eleven 
      comparative studies involving 959 SSc patients and 1739 controls were included in 
      the meta-analysis. No association was found between SSc and the CTLA-4 +49 A/G 
      polymorphism (OR for the +49 G allele = 1.032, 95% CI = 0.830-1.283, p = 0.779). 
      However, an association between SSc and the CTLA-4 -318 TT + TC genotype 
      (OR = 1.642, 95% CI = 1.034-2.609, p = 0.036). Meta-analyses failed to reveal an 
      association between SSc and CTLA-4 -1722 C/T, MCP-1 -2518 A/G polymorphisms. 
      CONCLUSIONS: This meta-analysis of published data shows that the CTLA-4 -318 C/T 
      polymorphism confers susceptibility to SSc.
FAU - Song, Gwan Gyu
AU  - Song GG
AD  - Division of Rheumatology, Department of Internal Medicine, Korea University 
      College of Medicine, Seoul 136-705, Korea.
FAU - Lee, Young Ho
AU  - Lee YH
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20130619
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (CCL2 protein, human)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Asian People/genetics
MH  - CTLA-4 Antigen/*genetics
MH  - Chemokine CCL2/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Scleroderma, Systemic/*genetics
MH  - White People/genetics
EDAT- 2013/06/21 06:00
MHDA- 2014/02/12 06:00
CRDT- 2013/06/21 06:00
PHST- 2013/06/21 06:00 [entrez]
PHST- 2013/06/21 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - 10.3109/08820139.2013.789910 [doi]
PST - ppublish
SO  - Immunol Invest. 2013;42(6):481-92. doi: 10.3109/08820139.2013.789910. Epub 2013 
      Jun 19.