PMID- 23783372
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20220409
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 68
IP  - 11
DP  - 2013 Nov
TI  - The five-repetition sit-to-stand test as a functional outcome measure in COPD.
PG  - 1015-20
LID - 10.1136/thoraxjnl-2013-203576 [doi]
AB  - BACKGROUND: Moving from sitting to standing is a common activity of daily living. 
      The five-repetition sit-to-stand test (5STS) is a test of lower limb function 
      that measures the fastest time taken to stand five times from a chair with arms 
      folded. The 5STS has been validated in healthy community-dwelling adults, but 
      data in chronic obstructive pulmonary disease (COPD) populations are lacking. 
      AIMS: To determine the reliability, validity and responsiveness of the 5STS in 
      patients with COPD. METHODS: Test-retest and interobserver reliability of the 
      5STS was measured in 50 patients with COPD. To address construct validity we 
      collected data on the 5STS, exercise capacity (incremental shuttle walk (ISW)), 
      lower limb strength (quadriceps maximum voluntary contraction (QMVC)), health 
      status (St George's Respiratory Questionnaire (SGRQ)) and composite mortality 
      indices (Age Dyspnoea Obstruction index (ADO), BODE index (iBODE)). 
      Responsiveness was determined by measuring 5STS before and after outpatient 
      pulmonary rehabilitation (PR) in 239 patients. Minimum clinically important 
      difference (MCID) was estimated using anchor-based methods. RESULTS: Test-retest 
      and interobserver intraclass correlation coefficients were 0.97 and 0.99, 
      respectively. 5STS time correlated significantly with ISW, QMVC, SGRQ, ADO and 
      iBODE (r=-0.59, -0.38, 0.35, 0.42 and 0.46, respectively; all p<0.001). Median 
      (25th, 75th centiles) 5STS time decreased with PR (Pre: 14.1 (11.5, 21.3) vs 
      Post: 12.4 (10.2, 16.3) s; p<0.001). Using different anchors, a conservative 
      estimate for the MCID was 1.7 s. CONCLUSIONS: The 5STS is reliable, valid and 
      responsive in patients with COPD with an estimated MCID of 1.7 s. It is a 
      practical functional outcome measure suitable for use in most healthcare 
      settings.
FAU - Jones, Sarah E
AU  - Jones SE
AD  - NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College, , Harefield, UK.
FAU - Kon, Samantha S C
AU  - Kon SS
FAU - Canavan, Jane L
AU  - Canavan JL
FAU - Patel, Mehul S
AU  - Patel MS
FAU - Clark, Amy L
AU  - Clark AL
FAU - Nolan, Claire M
AU  - Nolan CM
FAU - Polkey, Michael I
AU  - Polkey MI
FAU - Man, William D-C
AU  - Man WD
LA  - eng
GR  - CTF-01-12-04/DH_/Department of Health/United Kingdom
GR  - DHCS/07/07/009/DH_/Department of Health/United Kingdom
GR  - G1002113/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130619
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Exercise Test/*methods
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Male
MH  - Observer Variation
MH  - Posture/physiology
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology/rehabilitation
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires
MH  - Walking/*physiology
OTO - NOTNLM
OT  - COPD Pathology
OT  - Exercise
OT  - Pulmonary Rehabilitation
EDAT- 2013/06/21 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/06/21 06:00
PHST- 2013/06/21 06:00 [entrez]
PHST- 2013/06/21 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - thoraxjnl-2013-203576 [pii]
AID - 10.1136/thoraxjnl-2013-203576 [doi]
PST - ppublish
SO  - Thorax. 2013 Nov;68(11):1015-20. doi: 10.1136/thoraxjnl-2013-203576. Epub 2013 
      Jun 19.